摘要
目的探讨促红细胞生成素产生肝细胞激酶受体A10(EphA10)在胃癌和癌旁组织中的表达情况, 分析其与临床特征和预后的相关性。方法回顾性分析2018年1月至2023年12月东部战区空军医院112例胃癌患者的临床资料。采用EnVision免疫组织化学染色方法检测术后石蜡包埋标本胃癌和癌旁组织中EphA10表达情况。分析EphA10表达与临床病理特征的关系。绘制Kaplan-Meier生存曲线, 比较采用log-rank检验;采用多因素Cox回归分析影响胃癌患者总生存期的独立危险因素。结果胃癌组织中EphA10阳性表达率明显高于癌旁组织[44.6%(50/112)比0], 差异有统计学意义(χ^(2) = 64.37, P<0.01)。胃癌患者癌组织EphA10阳性表达与肿瘤长径、分化程度、TNM分期和淋巴结转移有关(P<0.01或<0.05), 与年龄、性别和远处转移无关(P>0.05)。Kaplan-Meier生存曲线分析结果显示, EphA10阳性表达患者中位总生存期明显低于EphA10阴性表达患者[18个月比48个月], 差异有统计学意义(log-rankχ^(2) = 53.66, P<0.01)。多因素Cox回归分析结果显示, 肿瘤长径≥3 cm、TNM分期Ⅲ~Ⅳ期、淋巴结转移和EphA10阳性表达是影响胃癌患者总生存期的独立危险因素(HR = 1.250、1.515、1.321和0.831, 95%CI 1.143~1.368、1.267~1.813、1.168~1.497和0.756~0.913, P<0.01或<0.05)。结论 EphA10在胃癌组织中表达上调, 其表达水平与临床病理特征具有相关性, EphA10可作为临床评估胃癌患者预后的参考指标之一。
ObjectiveTo investigate the expression of erythropoietin-producing hepatocyte kinase receptor A10(EphA10)in gastric cancer and adjacent tissues,and analyze its correlation with clinical features and prognosis.Methods The clinical data of 112 patients with gastric cancer from January 2018 to December 2023 in Eastern Theater Command Air Force Hospital were retrospectively analyzed.The expression of EphA10 in gastric cancer and adjacent tissues was detected by EnVision immunohistochemical staining.The relationship between EphA10 expression and clinicopathological features was analyzed.The Kaplan-Meier survival curve was drawn,and the comparison used the log-rank test.Multivariate Cox regression was used to analyze the independent risk factors of the overall survival time in patients with gastric cancer.Results The positive expression rate of EphA10 in gastric cancer tissues was significantly higher than that in adjacent tissues:44.6%(50/112)vs.0,and there was statistical difference(χ^(2)=64.37,P<0.01).In patients with gastric cancer,the positive expression of EphA10 in gastric cancer tissues was correlated with tumor long diameter,differentiation,TNM stage and lymph node metastasis(P<0.01 or<0.05),but without age,gender and distant metastasis(P>0.05).Kaplan-Meier survival curve analysis result showed that the median overall survival time in patients with positive EphA10 expression was significantly lower than that in patients with negative EphA10 expression:18 months vs.48 months,and there was statistical difference(log-rank χ^(2)=53.66,P<0.01).Multivariate Cox regression analysis result showed that tumor long diameter≥3 cm,TNM stage II to IV,lymph node metastasis and EphA10 positive expression were the independent risk factors of the overall survival time in patients with gastric cancer(HR=1.250,1.515,1.321 and 0.831;95%CI 1.143 to 1.368,1.267 to 1.813,1.168 to 1.497 and 0.756 to 0.913;P<0.01 or<0.05).Conclusions The expression level of EphA10 in gastric cancer tissues is up-regulated,and its expression level is correlated with the clinicopathological features.EphA10 can be used as one of the reference indicators for clinical prognosis evaluation in patients with gastric cancer.
作者
翁诗雅
赵明洁
袁平
李彦
余康捷
冷冬妮
Weng Shiya;Zhao Mingjie;Yuan Ping;Li Yan;Yu Kangjie;Leng Dongni(Department of Pathology,Eastern Theater Command Air Force Hospital,Nanjing 210002,China)
出处
《中国医师进修杂志》
2025年第7期603-608,共6页
Chinese Journal of Postgraduates of Medicine
基金
东部战区空军医院院级课题(22YY002)。
关键词
胃肿瘤
受体
Eph家族
免疫组织化学
预后
Stomach neoplasms
Receptors,Eph family
Immunohistochemistry
Prognosis
