摘要
目的分析血清同型半胱氨酸(Hcy)、胱抑素C(CysC)、C-反应蛋白(CRP)、肌酸激酶同工酶(CK-MB)、天冬氨酸转氨酶(AST)与冠心病患者冠状动脉(冠脉)狭窄程度的相关性。方法选择2021年4月—2023年4月毕节市中医院收治的91例冠心病患者作为研究对象,纳入观察组;另外选择同期在该院体检的85例健康体检者纳入对照组。采集所有受检者静脉血样本,使用全自动生化分析仪检测Hcy、CysC、CRP、CK-MB、AST,比较两组上述指标水平差异;根据不同冠脉病变程度Gensini评分将冠心病患者分为低危组(36例)、中危组(31例)、高危组(24例),比较各组Hcy、CysC、CRP、CK-MB、AST水平差异;采用Pearson相关性分析法考察Hcy、CysC、CRP、CK-MB、AST与Gensini评分的相关性。结果观察组血清Hcy、CysC、CRP、CK-MB、AST水平均显著高于对照组〔Hcy(μmol/L):23.46±2.59比8.77±1.36;CysC(mg/L):2.41±0.23比0.74±0.10;CRP(mg/L):12.59±2.47比5.31±0.89;CK-MB(U/L):30.94±5.31比15.39±2.34;AST(U/L):51.46±6.77比30.53±4.17;均P<0.05〕。冠心病高危组的血清Hcy、CysC、CRP、CK-MB、AST水平均显著高于中危组和低危组〔Hcy(μmol/L):32.88±4.05比27.64±3.21、22.71±2.30;CysC(mg/L):3.86±0.65比3.05±0.53、2.45±0.41;CRP(mg/L):19.75±3.26比15.94±2.81、12.35±2.05;CK-MB(U/L):49.84±6.31比40.66±5.21、30.75±4.89;AST(U/L):64.75±8.94比58.94±7.57、52.36±7.01;均P<0.05〕,且中危组的血清Hcy、CysC、CRP、CK-MB、AST水平均显著高于低危组(均P<0.05)。Pearson相关性分析结果显示,Hcy、CysC、CRP、CK-MB、AST与Gensini评分均呈正相关(r值分别为0.573、0.624、0.589、0.665、0.539,均P<0.001)。结论冠心病患者的血清Hcy、CysC、CRP、CK-MB、AST均呈异常高表达,且与患者冠脉狭窄程度呈正相关。
Objective To study the correlation of serum homocysteine(Hcy),cystatin C(CysC),C-reactive protein(CRP),creatine kinase isoenzyme(CK-MB),aspartate aminotransferase(AST)with the severity of coronary stenosis in coronary heart disease patients.Methods The 91 cases of coronary heart disease admitted in Bijie Hospital of Traditional Chinese Medicine during the period of April 2021 to April 2023 were taken as the subjects and included in the observation group.And 85 cases of healthy controls who received health examination over the same period were regarded as the control group.The venous blood samples from two groups of subjects were collected,a fully automated biochemical analyzer was used to detect the levels of Hcy,CysC,CRP,CK-MB and AST,and the differences between the two groups were compared.According to Gensini score of different degrees of coronary artery disease,the patients with coronary heart disease were divided into low-risk group(36 cases),medium-risk group(31 cases)and high-risk group(24 cases),and the differences in Hcy,CysC,CRP,CK-MB and AST levels among the groups were compared.Pearson correlation analysis was used to investigate the correlation between Hcy,CysC,CRP,CK-MB,AST and Gensini score.Results The levels of serum Hcy,CysC,CRP,CK-MB and AST in observation group were significantly higher than those in control group[Hcy(μmol/L):23.46±2.59 vs.8.77±1.36;Cys-C(mg/L):2.41±0.23 vs.0.74±0.10;CRP(mg/L):12.59±2.47 vs.5.31±0.89;CK-MB(U/L):30.94±5.31 vs.15.39±2.34;AST(U/L):51.46±6.77 vs.30.53±4.17;all P<0.05].The serum levels of Hcy,CysC,CRP,CK-MB and AST in high-risk group were significantly higher than those in medium-risk group and low-risk group[Hcy(μmol/L):32.88±4.05 vs.27.64±3.21,22.71±2.30;Cys-C(mg/L):3.86±0.65 vs.3.05±0.53,2.45±0.41;CRP(mg/L):19.75±3.26 vs.15.94±2.81,12.35±2.05;CK-MB(U/L):49.84±6.31 vs.40.66±5.21,30.75±4.89;AST(U/L):64.75±8.94 vs.58.94±7.57,52.36±7.01;all P<0.05].The levels of serum Hcy,CysC,CRP,CK-MB and AST in moderate-risk group were significantly higher than those in low-risk group(all P<0.05).The results of Pearson correlation analysis showed that Hcy,CysC,CRP,CK-MB and AST were positively correlated with Gensini scores(r values were 0.573,0.624,0.589,0.665 and 0.539,respectively,all P<0.001).Conclusion Serum Hcy,CysC,CRP,CK-MB and AST are all abnormally highly expressed in patients with coronary heart disease,and are positively correlated with the degree of coronary stenosis.
作者
孙鹏
程新媛
Sun Peng;Cheng Xinyuan(Department of Clinical Laboratory,Bijie Hospital of Traditional Chinese Medicine,Bijie 551700,Guizhou,China)
出处
《实用检验医师杂志》
2025年第2期102-105,共4页
Chinese Journal of Clinical Pathologist
关键词
冠心病
冠状动脉狭窄
同型半胱氨酸
胱抑素C
相关性
Coronary heart disease
Coronary artery stenosis
Homocysteine
Cystatin C
Correlation
