摘要
Metabolism-associated fatty liver disease(MAFLD)is a spectrum of chronic liver diseases caused by the abnormal accumulation of fat in the liver,which is becoming increasingly serious with the rise in obesity rates worldwide.Studies have shown that the interaction between lipid droplets and mitochondria plays an important role in the development and progression of MAFLD.In particular,peridroplet mitochondria(PDM),as a unique class of mitochondrial subpopulations,play a key function in lipid metabolism through spatial proximity and functional synergy.The current study revealed the functional heterogeneity of PDM from different tissue sources by optimizing PDM isolation techniques(e.g.,differential centrifugation combined with protease-assisted method),which provided a theoretical basis for targeting lipid droplet-mitochondrial interactions to intervene in MAFLD.Therefore,this paper reviews the morphology,function and isolation methods of PDM,as well as the relationship between lipid droplet-mitochondrial interactions and MAFLD,with the aim of promoting the development of MAFLD intervention strategies based on lipid droplet-mitochondrial interactions.
基金
supported by National Key Research and Development Program of China(No.2023YFF0724803)
National Science Foundation of China(No.82274424)
General Project of Traditional Chinese Medicine Joint Special Project of Yunnan Provincial Department of Science and Technology in 2024(No.202401AZ070001-038)
Scientific Research Fund Project of Yunnan Provincial Education Department(No.2025Y0634,No.2025Y0627).
