摘要
目的 探讨内皮细胞特异性分子1(endothelial cell specific molecule-1,ESM-1)在阻塞性睡眠呼吸暂停(OSA)患者中的表达特征,通过分析其与黏附分子的相关性,阐明ESM-1在OSA相关血管内皮损伤中的调控机制。方法 本研究为横断面研究,研究对象为2017年3月~2018年1月在首都医科大学附属北京安贞医院睡眠医学中心接受多导睡眠监测(PSG)患者,根据入选标准,最终纳入161例参与者,分为OSA组(n=118)和对照组(n=43)。收集人口统计数据和PSG参数。应用Luminex检测血浆中ESM-1、细胞间黏附分子1(ICAM-1)及血管细胞黏附分子1(VCAM-1)的细胞因子水平。结果 与对照组相比,OSA组患者的血浆ESM-1水平显著升高[819.73(612.36~1393.47)pg/ml]vs.[286.17(114.48~513.81)pg/ml,P<0.001]。经多因素校正后,ESM-1水平每升高100 pg/ml,OSA患病风险增加2.162倍(OR=2.162,95%CI=1.522~3.072)。ESM-1浓度与内皮功能障碍标志物ICAM-1/VCAM-1呈显著正相关(β=1.977,95%CI=1.429~2.734,P<0.001)。结论 OSA患者血浆ESM-1水平显著升高且与黏附分子水平密切关联,提示ESM-1可能作为评估内皮功能障碍的新型生物标志物,并具有独立预测OSA风险的临床价值。
OBJECTIVE This study investigated the clinical implications of endothelial cell-specific molecule 1(ESM-1)in obstructive sleep apnea(OSA)patients,with particular focus on its dynamic correlation with adhesion molecules,aiming to elucidate the regulatory role of ESM-1 in OSA-associated vascular endothelial impairment.METHODS This cross-sectional study enrolled participants undergoing polysomnography(PSG)at the Sleep Medicine Center of Beijing Anzhen Hospital,Capital Medical University between March 2017 and January 2018.Based on the inclusion criteria,161 participants were ultimately included and divided into OSA group(n=118)and control group(n=43).Demographic data and polysomnography parameters were collected.We used a powerful high-throughput Multiplex Immunobead Assay technology to simultaneously test plasm cytokines levels of ESM-1,inter-cellular adhesion molecule 1(ICAM-1),vascular cell adhesion molecule 1(VCAM-1).Circulating C-reactive protein(CRP)and homocysteine(Hcy)were detected by routine blood chemistry panel.RESULTS Circulating ESM-1 levels were significantly elevated in patients with OSA compared with healthy controls[819.73(612.36-1393.47)pg/ml]vs.[286.17(114.48-513.81)pg/ml,P<0.001].After adjusting for confounding factors,we found that circulating ESM-1 levels were an independent risk factor for OSA(odds ratio=2.162,95%CI=1.522-3.072,P<0.001)and circulating ESM-1 levels were positively associated with ICAM-1 and VCAM-1 levels(β=1.977,95%CI=1.429-2.734,P<0.001).CONCLUSION Circulating ESM-1 levels were significantly increased in patients with OSA,which is closely related with adhesion molecules levels.ESM-1 may be a surrogate endothelial dysfunction marker and an independent risk factor for OSA.
作者
张丽川
王建宏
陈志婷
孙智甫
冯燕军
于湛
孙海丽
ZHANG Lichuan;WANG Jianhong;CHEN Zhiting;SUN Zhifu;FENG Yanjun;YU Zhan;SUN Haili(Department of Otolaryngology Head and Neck Surgery,Beijing Anzhen Hospital,Capital Medical University,Beijing,100029,China;Beijing Institute of Heart,Lung and Blood Vessel Diseases,Beijing,100029,China)
出处
《中国耳鼻咽喉头颈外科》
2025年第5期323-328,共6页
Chinese Archives of Otolaryngology-Head and Neck Surgery
