摘要
阿尔茨海默病(Alzheimer's disease,AD)和骨质疏松(osteoporosis,OP)都是与年龄相关的退行性疾病,主要发生在60岁以上的老年人群中,并且在老龄化人口中成为越来越常见的组合疾病,极大地加重了家庭和社会的负担,已有研究证明,临床上有多种因素可刺激和加速AD和OP的发生,本综述主要对AD和OP的共同发病机制进行研究,并对AD小鼠模型体内维生素D、维生素K水平、信号通路、载脂蛋白及神经炎症等发病因素进行了讨论,此外,还对这两种疾病的潜在的治疗方法进行了阐述。
Alzheimer's disease(AD)and osteoporosis(OP)are both age-related degenerative diseases,which mainly occur in the elderly population over the age of 60,and are becoming an increasingly common combination in the aging population.It has been proved that a variety of factors can stimulate and accelerate the occurrence of AD and OP in clinical practice.This review mainly studies the common pathogenesis of AD and OP,and discusses the pathogenesis factors such as vitamin D and vitamin K levels,signaling pathways,apolipoprotein and neuroinflammation in AD mouse models.In addition,potential treatments for these two diseases are described.
作者
荆超楠
王江波
张冠群
Chaonan JING;Jiangbo WANG;Guanqun ZHANG(Department of Neurology,Affiliated Clinical College of Xuzhou Medical University,Xuzhou 221004,Jiangsu,China;Department of Neurology,Southeast University Affiliated Xuzhou Central Hospital,Xuzhou 221000,Jiangsu,China)
出处
《阿尔茨海默病及相关病杂志》
2025年第4期278-284,共7页
Chinese Journal of Alzheimer's Disease and Related Disorders
