摘要
支气管哮喘(以下简称哮喘)是一种常见的慢性呼吸系统疾病,其发病具有明显的性别差异。流行病学调查显示,成年女性哮喘的发病率及严重程度均明显高于男性。目前认为,这种性别差异可能与性激素有关。关于性激素与哮喘的关系,雌激素和孕酮对哮喘病理生理过程中气道的作用已被广泛研究,然而,雄激素在哮喘发病中的作用机制尚不明确。近年来,研究发现雄激素及其受体能够通过免疫细胞在哮喘中发挥抗炎作用。此外,它们还具有降低气道高反应性、松弛气道平滑肌、改善肺功能等功效。本文对雄激素及雄激素受体在哮喘中的研究进展进行了综述,旨在深入理解性激素与哮喘之间的关系,并为未来哮喘的治疗提供更多可行方案。
Bronchial asthma(hereinafter referred to as asthma)is a common chronic respiratory disease with significant gender differences.Epidemiologic surveys show that both the incidence and severity of asthma are significantly higher in adult females than in males.It is now believed that gender differences in asthma may be related to sex hormones,and the airway effects of estrogen and progesterone on asthma pathophysiology have been extensively studied.However,the mechanism of androgens in asthma is not clear.In recent years,some new studies have found that androgens and androgen receptors can exert anti-inflammatory effects in asthma through immune cells;moreover,they can also decrease airway hyperresponsiveness,relax airway smooth muscle,and improve lung function.This article reviews the progress of androgens and androgen receptors in asthma to deepen our understanding of the relationship between sex hormones and asthma,providing more options for future asthma treatment.
作者
孟野松
徐子骞
倪灏然
李利
商艳
MENG Yesong;XU Ziqian;NI Haoran;LI Li;SHANG Yan(Department of Respiratory and Critical Care Medicine,The First Affiliated Hospital of Naval Medical University(Second Military Medical University),Shanghai 200433,China;Department of General Practice,The First Affiliated Hospital of Naval Medical University(Second Military Medical University),Shanghai 200433,China)
出处
《海军军医大学学报》
北大核心
2025年第7期910-915,共6页
Academic Journal of Naval Medical University
基金
国家自然科学基金(82170033)
上海市虹口区卫生健康委员会医学科研课题(虹卫2302-43)
浙江省基础公益研究计划项目(LQ22H010001)。
