摘要
目的研究41种炎性因子与肝癌风险之间的因果关系。方法使用来自英国生物银行的全基因组关联研究(GWAS)数据库(GCST90043858,n=456348)和来自基于芬兰人群的41种炎性因子的GWAS数据集(n=8293)进行两样本孟德尔随机化(MR)研究,通过筛选与41种炎性因子显著相关的遗传变异作为工具变量(IVs),使用逆方差加权(IVW)法作为主要分析方法,并辅以MR Egger回归、加权中位数法及多效性检验以确保结果的稳健性。结果基因预测的IL-5(OR:2.15,95%CI:1.05~4.39,P=0.036)和IL-17(OR:3.35,95%CI:1.36~8.25,P=0.008)水平升高与肝癌风险增加相关。结论IL-5与IL-17和肝癌风险存在因果关系,提示其可能为肝癌风险标志物,靶向调控炎性通路或为肝癌防治提供新方向。
Objective To investigate the causal relationship between 41 inflammatory factors and hepatocellular carcinoma(HCC).Methods A two-sample Mendelian randomization(MR)analysis was conducted using genome-wide association study(GWAS)data from the UK Biobank(GCST90043858,n=456348)and a Finnish population-based GWAS dataset of 41 inflammatory factors(n=8293).Genetic variants significantly associated with the 41 inflammatory factors were selected as instrumental variables(IVs).The inverse-variance weighted(IVW)method was used as the primary analysis,supplemented by MR Egger regression,weighted median method,and pleiotropy tests to ensure the robustness of the results.Results Genetically predicted IL-5(OR:2.15,95%CI:1.05-4.39,P=0.036)and IL-17(OR:3.35,95%CI:1.36-8.25,P=0.008)were significantly associated with an increased risk of liver cancer.Conclusion IL-5 and IL-17 exhibit a causal relationship with hepatocellular carcinoma risk,suggesting their potential as biomarkers for liver cancer.Targeting inflammatory signaling pathways may provide novel strategies for the prevention and treatment of HCC.
作者
尹湘齐
肖晋昌
顾玉明
YIN Xiangqi;XIAO Jinchang;GU Yuming(Department of General Practice,Affiliated Hospital of Xuzhou Medical University,Xuzhou 221000,China;Interventional Radiology,Affiliated Hospital of Xuzhou Medical University,Xuzhou 221000,China)
出处
《免疫学杂志》
2025年第4期269-273,288,共6页
Immunological Journal
