摘要
Mesoporous silica nanoparticles(MsNs)are thought to be an attractive drug delivery material because of their advantages including high specific surface area,tunable pore size and morphology,easy sur-face modification and good biocompatibility.However,as a result of the poor biodegradability of MsNs,their biomedical applications are limited.To break the bottleneck of limited biomedical applications of MSNs,more and more researchers tend to design biodegradable MSNs(b-MSNs)nanosystems to obtain biodegradable as well as safe and reliable drug delivery carriers.In this review,we focused on sum-marizing strategies to improve the degradability of MsNs and innovatively proposed a series of advan-tages of b-MsNs,including controlled cargo release behavior,multifunctional frameworks,nano-catalysis,bio-imaging capabilities and enhanced therapeutic effects.Based on these advantages,we have inno-vatively summarized the applications of b-MsNs for enhanced tumor theranostics,including enhanced chemotherapy,delivery of nanosensitizers,gas molecules and biomacromolecules,initiation of immune response,synergistic therapies and image-guided tumor diagnostics.Finally,the challenges and further clinical translation potential of nanosystems based on b-MsNs are fully discussed and prospected.We believe that such b-MsNs delivery carriers will provide a timely reference for further applications in tu-mor theranostics.
基金
from"XingLiao Talent Program"of Liaoning Province(No.XLYC2203156)
Shenyang Young and Middle-aged Science and Technology Innovation Talent Support Program(No.RC220397)are greatly acknowledged。
