摘要
归纳节律分子钟与线粒体质量的交互效应在运动和饮食干预下的最新研究动态,提出:在饮食方面,间歇性禁食可能通过线粒体自噬调节节律分子钟,从而促进健康;节律分子钟与线粒体动态变化的交互作用可有效避免高脂饮食引起的胰岛素抵抗;在运动方面,目前已明确PGC-1α、Fis1和HIF-1α分别在脂肪、肝脏和骨骼肌中与BMAL1存在交互效应,且运动可通过BMAL1-HIF-1α、CLOCK-线粒体自噬以及AMPK-SIRT1-PGC-1α调控节律分子钟与线粒体质量控制的交互效应。长期择时运动和/或不同运动强度/方式(如无氧运动、低氧运动、抗阻训练等)对线粒体质量和节律分子钟交互效应的调控作用有待进一步研究,线粒体自噬可能是其中的重要环节;运动是否通过节律分子钟与线粒体动态变化的交互效应改善高脂饮食诱导的代谢异常亦有待探索。
Based on summing up the latest research progress of the interaction between molecular clock and mitochondrial quality under exercise and dietary change,this study proposes that intermittent fasting may promote health by regulating the molecular clock through mitophagy.The interaction between the molecular clock and the mitochondria dynamics can effectively avoid insulin resistance caused by high fat diet.In terms of sports,it has been elucidated that PGC-1α,Fis1 and HIF-1αcan interact with BMAL1 in adipose tissue,liver and skeletal muscle,respectively,and exercise regulates the interaction of molecular clock and MQC through BMAL1-HIF-1α,CLOCK-mitophagy,and AMPK-SIRT1-PGC-1α.However,the mechanism of long-term chrono-aerobic/anaerobic exercise and/or different exercise intensities/modes combined with intermittent fasting to regulate the interaction effect of mitochondrial quality and rhythmic molecular clock needs further study.Mitophagy may be the important link in this process.Whether exercise ameliorates metabolic abnormalities induced by high fat diet through the interaction effect of molecular clock and mitochondrial dynamics remains to be explored.
作者
张喆
钱帅伟
丁树哲
ZHANG Zhe;QIAN Shuaiwei;DING Shuzhe(Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education,East China Normal University,Shanghai 200241,China;Hubei Key Laboratory of Sports Training Monitoring,Wuhan Institute of Physical Education,Wuhan 430079,Hubei,China;College of Physical Education and Health,East China Normal University,Shanghai 200241,China)
出处
《上海体育大学学报》
北大核心
2025年第7期75-85,共11页
Journal of Shanghai University of Sport
基金
国家自然科学基金青年科学基金项目(32000836)
中央高校基本科研业务费专项资金资助项目(2018ECNU-HLYT048)。
关键词
节律分子钟
线粒体质量控制
运动
饮食
交互效应
rhythmic molecular clock
mitochondrial quality control
exercise
diet
interaction
