摘要
目的:观察奥沙西泮与劳拉西泮治疗广泛性焦虑障碍(GAD)的疗效及对事件相关电位P300(ERP-P300)、探究性眼动(EEM)的影响。方法:选取2021年1月—2024年1月商丘市第二人民医院收治的60例GAD患者作为研究对象,按照随机数表法分为对照组和观察组,每组各30例。对照组给予劳拉西泮0.5 mg/12 h口服,观察组给予奥沙西泮15 mg/8 h口服。两组患者均连续治疗6周。观察两组患者疗效、ERP-P300水平、EEM水平、肝功能和不良反应发生情况。结果:观察组总有效率高于对照组,差异有统计学意义(χ^(2)=4.320,P<0.05);治疗后,观察组P3潜伏期明显缩短,P3波幅较对照组低,差异均有统计学意义(t=2.044、4.270,P<0.05);治疗后,观察组凝视点数(NEF)、反应性探索评分(RSS)水平高于对照组,差异均有统计学意义(t=2.195、5.194,P<0.05);治疗后,观察组谷丙转氨酶(AST)、谷草转氨酶(ALT)水平均低于对照组,差异均有统计学意义(t=2.079、2.047,P<0.05);观察组患者的不良反应总发生率低于对照组,差异有统计学意义(χ^(2)=5.711,P<0.05)。结论:与劳拉西泮相比,奥沙西泮治疗GAD具有较好的疗效,能够显著改善EEM、ERP-P300水平,且其对肝功能的影响更小,安全性更高。
Objective:To observe the effects of oxazepam and lorazepam in the treatment of generalized anxiety disorder,and their influence on event-related potential P300(ERP-P300)and eye movement measurements.Methods:60 patients with generalized anxiety disorder who were admitted to the hospital from January 2021 to January 2024 were selected.Through using a table of random numbers,the subjects were divided into a control group and an observation group,with 30 cases in each group.The control group took lorazepam orally,0.5 mg/12 h,while the observation group took oxazepam orally,15 mg/8 h.Both groups underwent 6 weeks of continuous treatment.Therapeutic effects,ERP-P300,exploratory eye movement(EEM),liver function and the incidence of adverse reactions in the two groups were observed.Results:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(χ^(2)=4.320,P<0.05).After treatment,the latency of P3 in the observation group was significantly shortened,and the amplitude of P3 was lower than that in the control group.The differences were statistically significant(t=2.044,4.270;P<0.05).After treatment,the levels of Gaze points(NEF)and Reactive Exploration score(RSS)in the observation group were higher than those in the control group,and the differences were statistically significant(t=2.195,5.194;P<0.05).After treatment,the levels of alanine aminotransferase(AST)and aspartate aminotransferase(ALT)in the observation group were both lower than those in the control group,and the differences were statistically significant(t=2.079,2.047;P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(χ^(2)=5.711,P<0.05).Conclusion:Compared with lorazepam,oxazepam is more effective in the treatment of generalized anxiety disorder.It can significantly improve EEM and ERP P300,with less influence on liver function and higher safety.
作者
单筱雯
高孟英
Shan Xiaowen;Gao Mengying(The Fourth Department of Psychiatry,The Second People’s Hospital of Shangqiu City,Shangqiu,Henan,476000,China)
出处
《黑龙江医学》
2025年第14期1742-1745,共4页
Heilongjiang Medical Journal
