摘要
[目的]探索卵巢功能减退(diminished ovarian reserve,DOR)患者相关经穴病理状态下的热辐射特征改变,为诊断DOR筛选可能的优效经穴。[方法]采用横断面研究,DOR组纳入50例DOR患者,以50例匹配的健康受试者作为对照组,基于红外热成像技术观察两组受试者27个DOR治疗常见经穴的体表温度和经穴所在局部区域的体表温度,计算经穴温度与局部体表温度的差值作为该穴的相对温度,并比较两组受试者各经穴相对温度的差异。将差异有统计学意义的经穴纳入二元logistic回归分析,检验其红外相对温度与DOR的相关性。建立DOR发生风险的预测模型,使用受试者工作特征曲线(receiver operating characteristic curve,ROC)及曲线下面积(area under curve,AUC)评价预测模型的优效性。采用斯皮尔曼检验,分析DOR患者敏化穴位与改良Kuppermann评分指数(Kuppermann index,KI)的相关性。[结果]与对照组比较,观察组中脘、关元、气穴、四满(右)、上髎(右)的相对温度差异有统计学意义(P<0.05)。上髎(右)与KI存在负相关性(P<0.05)。二元logistic回归分析显示,中脘、四满(右)、上髎(右)红外相对温度是诊断DOR发生风险的主要因素,基于上述3个经穴相对温度构建的ROC曲线下面积为0.775。[结论]DOR患者相关经穴存在特异性热辐射改变,作为诊断DOR辅助手段具有一定有效性。
[Objective]To discover the changes in the thermal characteristics of meridian points in patients with diminished ovarian reserve(DOR)under pathological conditions,and to filter possible optimal acupoints for diagnosis of DOR.[Methods]There was a cross-sectional survey with 50 DOR patients and 50 healthy participants included,to detect the infrared thermal characteristics of certain acupoints,by observing the skin temperature and regional local temperature of 27 certain acupoints that were used to diagnose and treat DOR.The relative temperature was the acupoint’s temperature minus regional local temperature.Calculate the relative temperature of acupoints and compare the difference between two groups.Logistic regression analysis of acupoints that showed significant difference were used to examine whether DOR related acupoint temperature was the risk of DOR in women.Prediction model for increased DOR risk was constructed and evaluated by using the receiver operating characteristic curve(ROC)and the area under curve(AUC).Using Spearman’s test to analyze the correlation between the temperature of DOR-related and modified Kupperman Index(KI).[Results]Comparing with control group,the relative temperature of Zhongwan(CV12),Guanyuan(CV4),Qixue(KI13),right Siman(KI14)and right Shangliao(BL31)showed a significant decrease in DOR patients(P<0.05).Right Shangliao(BL31)was significantly negatively correlated with KI(P<0.05).According to the results of binary logistic regression,the relative temperatures of Zhongwan(CV12),right Siman(KI14)and right Shangliao(BL31)were closely bound up with DOR risk(P<0.05).The ROC curve was constructed basing on the temperature of the above three acupoints and the AUC of the prediction model was 0.775.[Conclusion]The acupoints related to DOR exhibit specific thermal radiation changes,demonstrating potential predictive value as an auxiliary diagnostic tool for DOR risk.
作者
刘涵予
孙颢珉
陈思淇
黄美
张雅俊
郦沛祺
马景
陈勤
方剑乔
邵晓梅
LIU Hanyu;SUN Haomin;CHEN Siqi(The Third Clinical Medical School,Zhejiang Chinese Medical University,Hangzhou 310053,China)
出处
《浙江中医药大学学报》
2025年第6期674-683,共10页
Journal of Zhejiang Chinese Medical University
基金
国家重点研发计划“中医药现代化”重点专项课题(2022YFC350401)。
关键词
卵巢功能减退
红外热辐射
经穴特异性
早期诊断
体表温度
经穴温度
经络脏腑相关
腧穴敏化
diminished ovarian reserve
infrared thermography
acupoint specificity
early diagnosis
body surface temperature
acupoint’s temperature
meridian-viscera correlation
acupoint sensitization
