摘要
目的分析硫酸羟氯喹致药物超敏反应综合征的特点,为临床合理用药提供参考。方法临床药师结合文献分析1例41岁诊断为结缔组织病干燥综合征可能的女性患者使用硫酸羟氯喹片2周后引起超敏反应综合征的诊治过程。通过检索中国知网、万方数据、PubMed等,收集羟氯喹致超敏反应的相关文献并进行分析,判断羟氯喹与超敏反应综合征关联性。结果临床药师与医师排查患者用药史和过敏史,判定硫酸羟氯喹与药物超敏反应综合征的关联性为很可能。对症治疗后患者好转。结论药物超敏反应综合征为硫酸羟氯喹罕见但严重的不良反应,血象可能具有隐匿性,人疱疹病毒筛查有助于判断药物超敏反应综合征,临床应警惕该不良反应。
Objective To analyze the characteristics of hypersensitivity syndrome induced by hydroxychloroquine.Methods The diagnosis and treatment process of hypersensitivity syndrome caused by hydroxychloroquine sulfate tablets in a 41-year-old female patient was analyzed based on literature,who had been diagnosed with a connective tissue disease or Sjogren’s syndrome(likely)after two weeks of treatment with hydroxychloroquine.Results Based on such data as the patient’s history of both medication and allergy,the correlation between hydroxychloroquine and hypersensitivity syndrome was determined as“probable”.The patient improved after symptomatic treatment.Conclusion Hypersensitivity syndrome is a rare but serious adverse reaction of hydroxychloroquine.The results of blood tests may not be revealing.Human herpes virus screening can help identify drug hypersensitivity syndrome.This adverse reaction deserves more attention in clinical practice.
作者
孙钟慧
刘英纯
董琪
张倩
杨静
SUN Zhonghui;LIU Yingchun;DONG Qi;ZHANG Qian;YANG Jing(Department of Pharmacy,Xi’an Fifth Hospital,Xi’an Shaanxi 710082,China;Department of Rheumatology and Immunology Xi’an Fifth Hospital,Xi’an Shaanxi 710082,China;Department of Rheumatology and Pain Xi’an Fifth Hospital,Xi’an Shaanxi 710082,China)
出处
《中国药物警戒》
2025年第6期689-692,共4页
Chinese Journal of Pharmacovigilance
基金
陕西省中医药科技创新提质扩能计划(TZKN-CXPT-04)
西安市卫生健康委项目(SZL202407)。
关键词
羟氯喹
药物超敏反应综合征
皮疹
结缔组织病干燥综合征
药品不良反应
Hydroxychloroquine Sulfate
Drug Induced Hypersensitivity Syndrome
Rash
Connective Tissue Disease
Adverse Drug Reactions
