摘要
表观遗传学机制在非酒精性脂肪性肝病(NAFLD)的发生、发展中扮演着至关重要的角色,尤其是在瘦人群体中,相关表观遗传学机制的研究为揭示NAFLD的潜在病因和治疗策略提供了新的线索和方向。本文介绍了近年表观遗传学在瘦型NAFLD发展中的作用,分析了瘦型NAFLD表观遗传学方面的最新研究进展,简述了表观遗传学的基本概念,包括DNA甲基化、组蛋白修饰和非编码RNA调控,并探讨了表观遗传学改变如何影响瘦型NAFLD的发病机制、疾病进展以及治疗策略。
Epigenetic mechanisms play a crucial role in the development and progression of nonalcoholic fatty liver disease(NAFLD),especially among lean individuals.The research on related epigenetic mechanisms has provided new clues and directions for revealing the underlying causes and treatment strategies of NAFLD.This article introduces the role of epigenetics in the development and progression of NAFLD among lean individuals in recent years,analyzes the latest research advances in the epigenetics of NAFLD in this population,and briefly describes the basic concepts of epigenetics,including DNA methylation,histone modifications,and non-coding RNA regulation.This article also discusses how epigenetic alterations impact the pathogenesis,disease progression,and treatment strategies of NAFLD in lean individuals.
作者
徐俊姣
刘素彤
张琪振
管雅捷
崔蓓蕾
吴文静
刘鸣昊
XU Junjiao;LIU Sutong;ZHANG Qizhen;GUAN Yajie;CUI Beilei;WU Wenjing;LIU Minghao(Department of Spleen,Stomach,Liver and Gallbladder,The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China;The First Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou 450000,China;Collaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine,Henan Province,Zhengzhou 450000,China;Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao,Henan Province,Zhengzhou 450000,China;Henan Academy of Traditional Chinese Medicine,Zhengzhou 450000,China)
出处
《临床肝胆病杂志》
北大核心
2025年第6期1161-1166,共6页
Journal of Clinical Hepatology
基金
国家自然科学基金(81904154,82205086)
河南省科技攻关计划(242102310500)
河南省“双一流”创建学科中医学科学研究专项(HSRP-DFCTCM-2023-1-10)。
