摘要
食管鳞癌是我国疾病负担严重的消化道肿瘤之一,严重威胁着我国居民的健康。代谢重编程是肿瘤生物学的一个新兴研究热点,在肿瘤的发生发展中发挥着关键作用。肿瘤代谢重编程是肿瘤细胞为了适应快速增殖和生长的需求,重新调整代谢途径的现象。这种代谢重塑不仅影响肿瘤细胞本身,还对免疫细胞功能及整个肿瘤免疫微环境产生深远影响。食管鳞癌代谢重编程的研究已经取得了一系列的进展,通过研究糖代谢、脂代谢和氨基酸代谢的机制改变,寻找代谢重编程相关重要靶点,有助于揭示食管鳞癌新的治疗靶点,提供针对性治疗策略,为提高治疗效果及改善预后提供方向。
Esophageal squamous cell carcinoma is one of the gastrointestinal tumors with a significant disease burden in China,posing a serious threat to public health.Metabolic reprogramming,an emerging research focus in tumor biology,plays a pivotal role in tumorigenesis and progression.It refers to the phenomenon in which cancer cells readjust their metabolic pathways to meet the demands of rapid proliferation and growth.This metabolic remodeling not only affects the tumor cells themselves but also exerts profound effects on immune cell function and the overall tumor immune microenvironment.Research on metabolic reprogramming in ESCC has achieved a series of advances.By investigating the mechanistic alterations in glucose metabolism,lipid metabolism,and amino acid metabolism,researchers aim to identify key metabolic reprogramming-related targets.These discoveries could help reveal novel therapeutic targets for ESCC,provide targeted treatment strategies,and offer new directions for improving therapeutic efficacy and prognosis.
作者
丁旭
苏翔宇
DING Xu;SU Xiangyu(Department of Oncology,Zhongda Hospital,Southeast University,Nanjing 210009,China)
出处
《临床肿瘤学杂志》
2025年第4期401-406,共6页
Chinese Clinical Oncology
关键词
食管鳞癌
代谢重编程
发生发展
治疗策略
Esophageal squamous cell carcinoma
Metabolic reprogramming
Development
Treatment strategies
