摘要
目的探究帕金森病(Parkinson’s disease,PD)患者嗅觉障碍发生的影响因素并进行系统评价与Meta分析。方法检索Sino Med、维普网、中国知网、万方数据知识服务平台、Web of Science、PubMed、Cochrane、Embase和MEDLINE数据库中关于PD嗅觉障碍影响因素的文献,检索时限自建库至2024年11月30日。结果共纳入13篇文献(总样本量2465例),共18项影响因素,总结为PD核心特征与进展因素,个体背景与环境交互因素2个主题。Meta分析表明年龄(MD=1.01,95%CI:-0.46~2.49,P=0.18)、吸烟(OR=0.88,95%CI:0.57~1.37,P=0.57)、便秘(OR=1.22,95%CI:0.38~3.93,P=0.74)并非影响PD患者嗅觉障碍的因素。结论PD嗅觉障碍影响因素多与非运动症状相关,针对非运动症状开展干预策略(如改善睡眠质量、补充维生素D、早期认知训练)可为延缓嗅觉障碍进展提供新思路。
Objective To explore the influencing factors of olfactory dysfunction in patients with Parkinson’s disease(PD)and conduct a systematic review and Meta-analysis.Methods Articles on factors influencing olfactory dysfunction in PD were retrieved from databases including SinoMed,VIP,China National Knowledge Infrastructure,Wanfang Data Knowledge Service Platform,Web of Science,PubMed,Cochrane,Embase,and MEDLINE.The search period spanned from the inception of each database to November 30,2024.Results A total of 13 articles(with a total sample size of 2465)were included,with a total of 18 influencing factors summarized as two themes:core features and progression factors of PD,and individual background and environmental interaction factors.Meta-analysis showed that age(MD=1.01,95%CI:-0.46-2.49,P=0.18),smoking(OR=0.88,95%CI:0.57-1.37,P=0.57),and constipation(OR=1.22,95%CI:0.38-3.93,P=0.74)were not factors affecting olfactory dysfunction in PD patients.Conclusion Factors influencing olfactory dysfunction in PD are predominantly associated with non-motor symptoms.Intervention strategies targeting non-motor symptoms(such as improving sleep quality,vitamin D supplementation,and early cognitive training)may provide novel approaches for delaying the progression of olfactory dysfunction.
作者
刘雨丹
李慧芳
李建春
翟亚仙
杨锦湄
沈云霞
LIU Yudan;LI Huifang;LI Jianchun;ZHAI Yaxian;YANG Jinmei;SHEN Yunxia(School of Nursing,Yunnan University of Traditional Chinese Medicine,Kunming 650500,Yunnan,China;Department of Geriatrics,the Third Affiliated Hospital of Yunnan University of Traditional Chinese Medicine,Kunming 650011,Yunnan,China;Department of Nursing,the Third Affiliated Hospital of Yunnan University of Traditional Chinese Medicine,Kunming 650011,Yunnan,China)
出处
《中国现代医生》
2025年第18期1-4,31,共5页
China Modern Doctor
基金
云南省科技厅科技计划项目(202301AZ070001-101)。
关键词
帕金森病
嗅觉障碍
影响因素
系统评价
Parkinson’s disease
Olfactory dysfunction
Influencing factors
Systematic review
