摘要
尽管Ⅰ期非小细胞肺癌是一种可通过手术治疗实现治愈的恶性肿瘤,但其5年复发率仍高达10%~29%,5年总生存率仅为77%~93.7%。因此,迫切需要更好的治疗策略来进一步提高Ⅰ期非小细胞肺癌患者的长期生存率。近年来,靶向治疗、免疫治疗在局部晚期非小细胞肺癌围术期阶段取得了重大突破。既往认为Ⅰ期非小细胞肺癌患者从辅助化疗中获益有限,但Ⅰ期患者能否从围术期靶向、免疫治疗中获益尚未有确定性结论。因此,针对目前Ⅰ期NSCLC围术期治疗存在的主要问题,包括围术期靶向或者免疫治疗适应证的选择与优化、单纯治疗或者联合治疗的方案的制定及优化策略、围术期靶向或者免疫治疗的最佳时限等问题,重庆肺癌精准治疗协作组开展集中论证,对这些关键问题给出了推荐意见,旨在为临床实践提供指导。
Although stageⅠnon-small cell lung cancer(NSCLC)is a type of malignant tumor that can be cured through surgical treatment,its 5-year recurrence rate is still as high as 10%-29%,with a 5-year survival rate of 77%-93.7%.Therefore,better treatment strategies are urgently needed to further improve the long-term survival rate of patients with stage I NSCLC.In recent years,major breakthroughs have been made in targeted therapy and immunotherapy for locally advanced NSCLC in the perioperative period.It was believed in the past that patients with stage I NSCLC had limited benefits from adjuvant chemotherapy,but there are still controversies over whether stage I patients can benefit from perioperative targeted therapy and immunotherapy.Therefore,Chongqing Precision Lung Oncology Group discusses the main issues in the treatment of stage I NSCLC in the perioperative period and provides related recommendations,including the selection and optimization of indications for perioperative targeting therapy or immunotherapy,the formulation and optimization of regimens and strategies for single therapy or combined therapy,and the optimal time of perioperative targeting therapy or immunotherapy,so as to provide guidance for clinical practice.
作者
张瑜
李梦侠
孙建国
重庆肺癌精准治疗协作组(CPLOG)
Zhang Yu;Li Mengxia;Sun Jianguo;Chongqing Precision Lung Oncology Group(Department of Oncology,Guizhou Provincial People’s Hospital;Department of Oncology,PLA Army Characteristic Medical Center;Department of Oncology,The Second Affiliated Hospital of Army Medical University;不详)
出处
《重庆医科大学学报》
北大核心
2025年第6期703-713,共11页
Journal of Chongqing Medical University
基金
重庆市技术创新与应用发展项目(重庆市科技局:CSTB2022TIAD-KPX0176)
重庆市科卫联合医学科研项目(重庆市卫生健康委员会:2023DBXM002)
重庆市医学领军人才项目(重庆市卫生健康委员会:YXLJ202401)
院级人才创新能力培养计划(陆军特色医学中心:ZXYZZKY07)
贵州省“优秀青年科技人才”项目(贵州省科学技术厅:黔科合平台人才-YQK[2023]021)。
关键词
非小细胞肺癌
Ⅰ期
围术期
专家共识
non-small cell lung cancer
stage I
perioperative period
expert consensus
