摘要
目的 探讨蛭芎胶囊联合丁苯酞治疗急性脑梗死的效果。方法 选取2021年1月至2023年12月辽宁省健康产业集团阜新矿总医院收治的80例急性脑梗死患者,随机分为观察组与对照组,各40例。对照组采用丁苯酞治疗,观察组采用蛭芎胶囊联合丁苯酞治疗。比较两组患者疗效和不良反应,检测平均血流速度(Vm)、脉动指数(PI)、收缩期峰值流速(PSV)、阻力指数(RI)、血液流变学指标、血清生长分化因子15(GDF-15)、同型半胱氨酸(Hcy)、正五聚蛋白3(PTX3)和CXC趋化因子16(CXCL-16)水平。结果 观察组治疗总有效率明显高于对照组(P<0.05);治疗后,两组脑循环动力学指标改善(P<0.05),且观察组Vm和PSV高于对照组(P<0.05),PI和RI低于对照组(P<0.05);治疗后,两组血细胞比容、红细胞沉降率、血小板平均体积和全血黏度降低(P<0.05),且观察组低于对照组(P<0.05);治疗后,两组血清GDF-15、Hcy、PTX3及CXCL-16水平降低(P<0.05),且观察组低于对照组(P<0.05);两组不良反应发生率无明显差异(P>0.05)。结论 蛭芎胶囊联合丁苯酞能明显提高急性脑梗死的疗效,改善脑血流动力学,机制可能与下调GDF-15、Hcy、PTX3及CXCL-16水平有关,且安全性较高。
Objective To explore the effect of Zhixiong Capsules combined with butylphthalide in the treatment of acute cerebral infarction.Methods Eighty patients with acute cerebral infarction admitted to Fuxin Mine General Hospital of Liaoning Health Industry Group from January 2021 to December 2023 were selected and randomly divided into an observation group and a control group,with 40 cases in each group.The control group was treated with butylphthalide,while the observation group was treated with Zhixiong Capsules combined with butylphthalide.The therapeutic effects and adverse reactions of the two groups of patients were compared,the levels of mean blood flow velocity(Vm),pulsation index(PI),peak systolic velocity(PSV),resistance index(RI),hemorheological indicators,serum growth differentiation factor 15(GDF-15),homocysteine(Hcy),pentagmoprotein 3(PTX3),and CXC chemokine 16(CXCL-16)were detected.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).After the treatment,the cerebral circulation dynamics indicators in both groups improved(P<0.05),and the Vm and PSV in the observation group were higher than those in the control group(P<0.05),while the PI and RI were lower than those in the control group(P<0.05).After the treatment,the hematocrit,erythrocyte sedimentation rate,mean platelet volume and whole blood viscosity in both groups decreased(P<0.05),and those in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of serum GDF-15,Hcy,PTX3 and CXCL-16 in both groups decreased(P<0.05),and those in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Zhixiong Capsules combined with butylphthalide can significantly improve the therapeutic effect of acute cerebral infarction and cerebral hemodynamics.The mechanism may be related to the down-regulation of GDF-15,Hcy,PTX3 and CXCL-16 levels,and it has a relatively high safety.
作者
韩雪
刘海兵
HAN Xue;LIU Hai-Bing(Department of Neurology,Fuxin Mine General Hospital,Liaoning Health Industry Group,Fuxin 123000,China)
出处
《中国药物经济学》
2025年第5期72-75,79,共5页
China Journal of Pharmaceutical Economics
关键词
蛭芎胶囊
丁苯酞
急性脑梗死
生长分化因子15
同型半胱氨酸
正五聚蛋白3
CXC趋化因子16
Zhixiong Capsules
Butylphthalein
Acute cerebral infarction
Growth differentiation factor 15
Monohomocysteine
Pentameric protein 3
CXC chemotactic factor 16
