摘要
狂犬病是由狂犬病病毒属病毒(Lyssavirus)引起的人畜共患病毒性疾病,狂犬病病毒(Rabies virus,RABV)是最主要病原体,99%的病例是通过动物尤其是犬咬伤传播。由于发病机制尚不清楚,治疗靶点较少,迄今为止尚无有效治疗方法,狂犬病在人类和其他哺乳动物中引起致命的脑炎并持续对世界许多地区的公共健康构成威胁。RABV感染依赖于宿主细胞,作为病毒感染分子机制基础的RABV病毒蛋白和宿主因子及其相互作用有待总结和分析;大量化合物通过多种机制对RABV发挥抗病毒作用;此外RABV自身的五种结构蛋白在病毒感染中起着重要作用,在这篇综述文章中,我们从不同角度讨论影响RABV感染的最新研究和进展,以更有效地了解和对抗这种致命疾病。
Rabies is a zoonotic viral disease caused by the rabies virus(RABV),the principal pathogen in the Lyssavirus genus.Approximately 99%of cases are transmitted through animal bites,particularly from dogs.Due to the unclear pathogenesis and limited treatment targets,no effective treatment exists to date.Rabies leads to fatal encephalitis in humans and other mammals and continues to pose a public health threat in many regions worldwide.RABV infection depends on host cellular factors,and the interactions between viral proteins and host factors,which form the basis of the molecular mechanisms of infection,still need to be summarized and analyzed.Many chemical compounds have demonstrated antiviral effects against RABV through various mechanisms.Additionally,the five structural proteins of RABV play critical roles in viral infection.This review discusses recent research and advancements on the factors influencing RABV infection from various perspectives,aiming to improve understanding and control of this deadly disease.
作者
方满新
李鹏成
屈嘉星
FANG Manxin;LI Pengcheng;QU Jiaxing(College of Life Sciences and Resource Environment,Yichun University,Yichun 336000)
出处
《病毒学报》
北大核心
2025年第3期978-989,共12页
Chinese Journal of Virology
基金
江西省“双千计划”(项目号:jxsq2019101056),题目:江西省引进类创新领军人才长期(青年)项目
宜春学院博士科研启动项目(项目号:210-3360119046),题目:非编码RNA在动物病毒感染中的作用和机制。
