摘要
本综述系统论述了α疱疹病毒US4基因编码的糖蛋白gG的特点及其在病毒感染、毒力、神经侵袭、趋化因子结合与天然免疫调控中的功能,分析了gG在调节趋化因子活性、影响神经信号传导等方面的机制及其在疫苗研发和诊断中的应用潜力,为进一步探索人类和动物α疱疹病毒US4基因的功能及其防控策略提供一定参考。
This review systematically examines the characteristics of glycoprotein gG encoded by the US4 gene of alphaherpesviruses and its roles in viral infection,virulence,neuroinvasion,chemokine binding,and innate immune regulation.The mechanism by which gG modulates chemokine activity and influences neural signal transduction,as well as its potential applications in vaccine development and diagnostics,are analyzed.This review provides a reference for further investigations into the function of the US4 gene in human and animal alphaherpesviruses and its implications for prevention and control strategies.
作者
邱洁
汪铭书
程安春
QIU Jie;WANG Mingshu;CHENG Anchun(Institute of Immunology,College of Animal Medicine,Sichuan Agricultural University,Chengdu 611130,China;Key Laboratory of Animal Epidemic Diseases and Human Health,Chengdu 611130,China;Engineering Research Center of Animal Epidemic Disease Prevention and Control,Ministry of Education,Chengdu 61l30,China;Sichuan International Joint Research Center for Animal Epidemic Disease Preventionand Control,Chengdu611130,China)
出处
《病毒学报》
北大核心
2025年第3期956-964,共9页
Chinese Journal of Virology
基金
财政部和农业农村部国家现代农业产业技术体系专项(项目号:CARS-42-17),题目:免疫抑制病防控。
