摘要
Most cancer cells harbor gross chromosomal alterations that result in an aneuploid karyotype.Lin et al.recently demonstrated that mammary epithelia from healthy women contain clonally expanded aneuploid cell populations that share considerable genomic traits with invasive breast tumors,potentially representing malignant precursors that have not yet evaded immunosurveillance[1].
基金
supported(as a PI unless otherwise indicated)by one NIH R01 grant(#CA271915)
by two Breakthrough Level 2 grants from the US DoD BCRP(#BC180476P1,#BC210945)
by a grant from the STARR Cancer Consortium(#I16--0064)
by a Transformative Breast Cancer Consortium Grant from the US DoD BCRP(#W81XWH2120034,PI:Formenti)
by a U54 grant from NIH/NCI(#CA274291,PI:Deasy,Formenti,Weichselbaum).by the 2019 Laura Ziskin Prize in Translational Research(#ZP-6177,PI:Formenti)from the Stand Up to Cancer(SU2C)
by a Mantle Cell Lymphoma Research Initiative(MCL-RI,PI:Chen-Kiang)grant from the Leukemia and Lymphoma Society(LLS)
by a Rapid Response Grant from the Functional Genomics Initiative(New York,US)
by a pre-SPORE grant(PI:Demaria,Formenti),a Collaborative Research Initiative Grant and a Clinical Trials Innovation Grant from the Sandra and Ed of Radiation Oncology at Weill Cornell Medicine(New York,US)
by startup funds from Fox Chase Cancer Center(Philadelphia,US)
by industrial collaborations with Lytix Biopharma(Oslo,Norway),Promontory(New York,US)and Onxeo(Paris,France)
by donations from Promontory(New York,US),the Luke Heller TECPR2 Foundation(Boston,US),Sotio a.s.(Prague,Czech Republic),Lytix Biopharma(Oslo,Norway),Onxeo(Paris,France),Ricerchiamo(Brescia,Italy),and Noxopharm(Chatswood,Australia)
supported by funding from Associazione Italiana per la Ricerca sul Cancro AIRC,IG 2022 ID.27685
CARESS Fondazione Piemontese per la Ricerca sul Cancro(FRPC)5×1000 Intramural Grant,and startup grants from the Italian Institute for Genomic Medicine and Compagnia di San Paolo.
