摘要
2023年中国心血管健康与疾病报告显示中国下肢动脉疾病(lower extremity arterial disease,LEAD)患病人数约为4530万,相比于2015年约增加2530万,随着LEAD患者数量的增加,越来越多的患者选择通过经皮腔内血管成形术(percutaneous transluminal angioplasty,PTA)进行介入治疗。这种微创手术通过扩张血管来改善血流,但术后可能出现支架内再狭窄(in-stent restenosis,ISR),这是一种影响PTA术后长期获益和预后的重要危险因素。中药因其多靶点作用和较少的不良作用,在一定程度上可以延缓ISR的发生及病情进展。文章旨在归纳总结传统中药及其有效成分在预防ISR方面的作用机制。中药能够通过多种途径有效干预ISR的发生与发展。例如,中药可以抑制血管内膜病理性增厚、减少新生动脉粥样硬化的形成、抗新生血栓以及发挥抗炎作用。此外,中药还可以调控血糖和血脂水平,稳定血压。通过探讨中药对ISR的影响,为临床治疗提供新的思路和策略,从而改善PTA患者的预后,提升他们的生活质量。
The China Cardiovascular Health and Disease Report 2023 shows that the number of people with lower extremity arterial disease(LEAD)in China is about 45.3 million,which is an increase of about 25.3 million compared with 2015.With the increase in the number of LEAD patients,more and more patients are choosing interventional therapy through percutaneous transluminal angioplasty(PTA)intervention.This minimally invasive procedure improves blood flow by dilating blood vessels,but post-procedure in-stent restenosis(ISR)may occur,which is an important risk factor affecting the long-term benefit and prognosis after PTA.Traditional Chinese medicine(TCM)can delay the occurrence and progression of ISR to a certain extent due to its multi-targeted effects and fewer adverse effects.The aim of this paper is to summarize the mechanism of action of traditional Chinese medicine and its active ingredients in preventing ISR.Chinese medicines can effectively intervene in the occurrence and development of ISR through multiple pathways.For example,they can inhibit pathological thickening of the vascular endothelium,reduce the formation of de novo atherosclerosis,resist de novo thrombosis,and exert anti-inflammatory effects.In addition,TCM can regulate blood glucose and lipid levels and stabilize blood pressure.By exploring the effects of TCM on ISR,we can provide new ideas and strategies for clinical treatment,thereby improving the prognosis of PTA patients and enhancing their quality of life.
作者
张玉
李强
ZHANG Yu;LI Qiang(Shandong University of Traditional Chinese Medicine,Jinan 250000,Shandong,China;Qingdao Hospital of Traditional Chinese Medicine,Qingdao 266000,Shandong,China)
出处
《辽宁中医药大学学报》
2025年第7期49-53,共5页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家自然科学基金(82172095)
青岛市中医药科研计划项目(2019-WJZD045,2020-zyy003)。
关键词
下肢动脉疾病
中药
支架植入术后再狭窄
lower extremity arterial disease
Chinese medicine
in-stent restenosis
