摘要
目的探讨气郁质对大学生抑制控制功能的影响及其神经电生理机制。方法通过《中医体质分类与判定标准》量表从大学生中筛选出平和质和气郁质人群,每组分别纳入35名被试。通过事件相关电位技术采集两组被试完成Flanker范式行为学指标(正确率、反应时)及脑电数据指标(N2、P3成分的波幅与潜伏期),探索两组在Flanker范式下的行为学差异及其神经电生理机制。结果与平和质组相比,气郁质组反应时较长(P=0.07);与一致条件相比,在不一致条件下的反应时较长(P<0.001),不一致条件下的正确率显著降低(P<0.001)。与平和质组相比,气郁质组的N2波幅较高(P<0.05)。N2潜伏期脑区主效应差异有统计学意义(P<0.001);对脑区做事后检验,额区Fz(Frontal lobe zero)大于额中央区FCz(Frontal lobe central zero)大于中央区Cz(Central zero)(P<0.05)。脑区主效应差异有统计学意义(P<0.001),对脑区做事后检验,额中央区FCz显著大于额区Fz(P<0.001);中央区Cz显著大于额区Fz,差异有统计学意义(P<0.001)。P3成分潜伏期一致刺激显著小于不一致刺激(P<0.001)。结论气郁质对大学生的抑制控制功能有不良影响,冲突的监测和控制能力下降是其可能的机制之一。
Objective To investigate the effect of Qi stagnation on inhibitory control function and its neuroelectrophysiological mechanism in college students.Methods The population of peace and Qi depression was screened from college students through the scale of“Classification and Judgment Criteria of Traditional Chinese Medicine Constitution”,and 35 subjects were included in each group.Combined with event-related potential technology,the two groups were collected to complete the Flanker paradigm behavioral indicators(accuracy,response time)and EEG data indicators(amplitude and latency of N2 and P3 components),and the behavioral differences and neuroelectrophysiological mechanisms between the two groups under the Flanker paradigm were explored.Results Compared with the flat group,the reaction time of the gas depression group was longer(P=0.07).Compared with the consistent dondition,the reaction time was longer under the inconsistent condition(P<0.001),and the accuracy rate was lower under the inconsistent condition significantly(P<0.001).Compared with the peaceful group,the N2 amplitude of the air depression group was higher(P<0.05).There was a statistically significant difference in the main effect of brain regions in the N2 latency period(P<0.001).Frontal lobe zero(Fz)in frontal region was greater than Frontal lobe central zero(FCz)in frontal region and greater than Central zero(Cz)in central region(P<0.05).There was a statistically significant difference in the main effect of brain region(P<0.001).FCz in the frontal central region was significantly greater than that in the frontal region Fz(P<0.001),and the difference was statistically significant in the central region Cz was significantly greater than that in the frontal region(P<0.001).The incubation period of P3 component was significantly smaller than that of inconsistent stimulation(P<0.001).Conclusion Qi stagnation has a negative effect on the inhibitory control function of college students,and the decline of conflict monitoring and control ability is one of the possible mechanisms.
作者
丁晓岐
刘永
侯俊林
赵紫薇
秦中朋
曹入元
詹向红
DING Xiaoqi;LIU Yong;HOU junlin;ZHAO Ziwei;QIN Zhongpeng;CAO Ruyuan;ZHAN Xianghong(Henan University of Chinese Medicine,Henan Province Engineering Technology Research Center for Chinese and Western Integrative Prevention and Treatment of Brain Cognitive Disease,Zhengzhou Key Laboratory for Chinese&Western Integrative Prevention and Treatment of Brain Cognitive Disease,Zhengzhou 450046,China;Department of Neurology,The Mine Hospital of Xuzhou,Xuzhou 221002,China)
出处
《世界科学技术-中医药现代化》
北大核心
2025年第5期1219-1227,共9页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委员会面上项目(81873208):肝失疏泄对正常人群和MCI患者认知功能衰退进程的影响及机制研究,负责人:詹向红
河南省双一流创建学科中医学科学研究专项(HSRP-DFCTCM-2023-1-02):负性情绪积累对aMCI患者执行功能的影响及疏肝法干预机制,负责人:詹向红
河南省“双一流“创建学科中医学科学研究专项(HSRP-DFCTCM-2023-7-16):基于ERPs技术探讨疏肝解郁对阈下抑郁个体记忆维持的影响及机制,负责人:赵紫薇。
