摘要
目的研究患有坏死性小肠结肠炎早产儿中,血清S100钙结合蛋白A12(S100A12)、人β-防御素(HBD)、25-羟维生素D在该病患儿中的表达以及与临床预后之间的关系。方法选取2022年9月至2023年9月在张家口市妇幼保健院产科出生,且出生2 h内入住我院新生儿科进行住院治疗的早产儿200例为研究对象。其中患有坏死性小肠结肠炎早产儿94例,健康早产儿106例。患病早产儿作为观察组,健康早产儿作为对照组。患病早产儿在经相关针对性治疗后分为预后良好组(n=61)和预后不良组(n=33)。比较对照组与观察组和预后良好组与预后不良组的血清S100A12、HBD、25-羟维生素D水平。结果与对照组早产儿的血清S100A12水平比较,观察组患儿水平相对较高(P<0.05);与对照组早产儿的HBD-1、HBD-2和25-羟维生素D水平比较,观察组患儿水平相对较低(P<0.05)。与预后良好组患儿的血清S100A12水平比较,预后不良组患儿水平相对较高;与预后良好组患儿HBD-1、25-羟维生素D和HBD-2水平比较,预后不良组患儿水平相对较低(P<0.05)。依照多因素分析,母亲年龄、HBD-2、体重、HBD-1、S100A12、用氧持续时间、25-羟维生素D水平、胎龄、输血、新生儿窒息都是影响早产儿坏死性小肠结肠炎预后的因素(P<0.05)。ROC结果显示,与S100A12、HBD、25-羟维生素D单项检测比较,联合检测早产儿坏死性小肠结肠炎预后的敏感度、特异度较高(P<0.05)。结论对于早产儿患有坏死性小肠结肠炎者,血清S100A12表达水平较高,HBD-1、HBD-2、25-羟维生素D表达水平相比健康早产儿较低,其与临床预后有很大联系。提示需更加关注患儿的血清S100A12、HBD、25-羟维生素D指标水平,做好早期的诊断,提高患儿预后。
Objective To study the correlation of the expression of serum S100A12,human beta-defensin(HBD),and 25-hydroxyvitamin D(25OHD)with clinical prognosis in premature infants with necrotizing enterocolitis(NEC).Methods From September 2022 to September 2023,200 premature infants born in the obstetrics department and admitted to the neonatology department within 2 h of birth in Zhangjiakou Maternal and Child Health Hospital were selected as the research subjects.There were 94 cases of NEC(observation group)and 106 cases of healthy(control group).Premature infants with NEC were divided into a good prognosis group(n=61)and a poor prognosis group(n=33)after targeted treatment.Serum S100A12,HBD,25OHD levels were compared between groups.Results Compared with those of healthy preterm infants,the preterm infants with NEC had significantly higher level of S100A12,and lower levels of HBD-1,HBD-2,and 25 OHD(P<0.05).Compared with those of NEC children with the good prognosis,the NEC children with the poor prognosis presented significantly higher level of S100A12,and lower levels of HBD-1,HBD-2,and 25OHD(P<0.05).The multivariate Logistic analysis revealed that maternal age,body weight,the levels of S100A12,HBD-1,HBD-2,25OHD,oxygen duration,gestational age,presence or absence of blood transfusion and neonatal asphyxia were all factors affecting the prognosis of the preterm infants with NSC(P<0.05).The receiver operator characteristic(ROC)results showed that the combined detection of S100A12,HBD,and 25OHD for NEC in premature infants had higher sensitivity and specificity in prognosis compared to their single detection(P<0.05).Conclusion The higher serum S100A12 and lower HBD-1,HBD-2 and 25OHD are found in preterm infants with NEC compared to those of healthy,which has a great association with their clinical prognosis.It is suggested that more attention should be paid to the serum levels of S100A12,HBD,and 25OHD in the pediatric patients,aim to make early diagnosis and improve their prognosis.
作者
冯茹清
马媛媛
李亚利
FENG Ruqing;MA Yuanyuan;LI Yali(Department of Neonatology,Zhangjiakou Maternal and Child Health Hospital,Hebei,Zhangjiakou 075000,China)
出处
《河北医药》
2025年第6期970-973,977,共5页
Hebei Medical Journal
基金
张家口市重点研发计划项目(编号:2322073D)。
关键词
早产儿坏死性小肠结肠炎
临床预后
用氧持续时间
单项检测
necrotizing enterocolitis in premature infants
clinical prognosis
oxygen duration
single detection
