摘要
目的分析胃食管反流病患者食管外症状的临床特征,并采用高分辨率测压(HRM)进行鉴别分析。方法选择96例胃食管反流病患者,根据临床表现分为反酸胃灼热组(n=46)和食管外症状组(n=50)。比较两组人口学特征、临床特征及HRM指标。采用ROC曲线分析HRM结果对食管外症状的诊断价值。结果食管外症状组GerdQ评分、食管外症状者占比、卧位弱酸反流次数、立位非酸反流次数、食管下括约肌(LES)静息压、LES长度、食团内部压力(IBP)高于反酸胃灼热组,反酸胃灼热者占比、食管上括约肌(UES)残余压、食管综合松弛压(IRP)、远端潜伏期(DL)低于反酸胃灼热组(P<0.05)。LES静息压、LES长度、UES残余压、IRP、DL及IBP对胃食管反流病患者发生食管外症状具有良好的预测价值(P<0.05)。结论合并食管外症状的胃食管反流病患者的弱酸及非酸反流更为严重,HRM对胃食管反流病患者发生食管外症状具有良好的预测价值。
Aim To analyze the clinical characteristics of extra-esophageal symptoms in patients with gastroesophageal reflux disease(GERD)and differentiate them using high-resolution manometry(HRM).Methods A total of 96 GERD patients were selected and divided into acid reflux/heartburn group(n=46)and extra-esophageal symptoms group(n=50)based on clinical manifestations.Demographic characteristics,clinical features,and HRM parameters were compared between the two groups.ROC curve analysis was performed to evaluate the predictive value of HRM for extra-esophageal symptoms.Results The extra-esophageal symptoms group had higher GerdQ scores,proportions extra-esophageal symptoms,supine weak acid reflux episodes,upright non-acid reflux episodes,lower esophageal sphincter(LES)resting pressure,LES length,and intrabolus pressure(IBP),but lower proportions of acid reflux/heartburn,upper esophageal sphincter(UES)residual pressure,integrated relaxation pressure(IRP),and distal latency(DL),compared with the acid reflux/heartburn group(P<0.05).LES resting pressure,LES length,UES residual pressure,IRP,DL,and IBP showed good predictive value for extra-esophageal symptoms in GERD patients(P<0.05).Conclusion GERD patients with extra-esophageal symptoms exhibit more severe weak acid and non-acid reflux.HRM demonstrates good predictive value for identifying extra-esophageal symptoms in GERD patients.
作者
杨琰
陈军
石振旺
YANG Yan;CHEN Jun;SHI Zhenwang(Department of Gastroenterology,Hefei Second People’s Hospital,Hefei 230000,Anhui,China)
出处
《中南医学科学杂志》
2025年第4期712-715,共4页
Medical Science Journal of Central South China
基金
合肥市卫健委应用研究重点项目(hwk2019ZD008)。
关键词
胃食管反流病
反酸胃灼热
食管外症状
HRM
gastroesophageal reflux disease
acid reflux/heartburn
extra-esophageal symptoms
HRM
