摘要
我国是全球结核病高负担国家之一,患者基数大。目前结核病的治疗以化疗为主,因治疗周期长且联用药物复杂,不良反应的发生不可避免。其中,精神心理不良反应较为常见,但因初期症状隐匿,缺乏特异性检测和评价指标,临床上易被忽视。本文综述国内外关于抗结核药物所致精神心理不良反应的发生率、危险因素、相关药物及其作用机制,以及管理策略的研究进展,旨在为此类不良反应的早期发现及干预提供理论依据和实践指导。
China is one of the countries with a high tuberculosis(TB)burden,with a large patient population.Currently,the primary treatment for TB is chemotherapy with anti-TB drugs.However,due to the prolonged treatment duration and the complexity of multidrug regimens,adverse reactions are inevitable.Among these,psychiatric and psychological adverse reactions are relatively common.However,they are often overlooked in clinical practice due to their insidious onset and the lack of specific diagnostic tools and evaluation criteria.This article reviews the latest research progress on the incidence,risk factors,related drugs and their mechanisms,as well as management strategies for psychiatric and psychological adverse reactions induced by anti-TB drugs,aiming to provide theoretical evidence and practical guidance for the early detection and intervention of such adverse reactions.
作者
王煜童
刘宇红
李亮
Wang Yutong;Liu Yuhong;Li Liang(Beijing Chest Hospital,Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute,Beijing 101149,China)
出处
《中国防痨杂志》
北大核心
2025年第7期947-953,共7页
Chinese Journal of Antituberculosis
基金
北京市卫生健康委员会高层次公共卫生技术人才建设项目(学科带头人-03-11)。
关键词
抗结核药
药物毒性
精神障碍
综述文献(主题)
Antitubercular agents
Drug toxicity
Mental disorders
Review literature as topic
