摘要
缺血性脑血管病严重威胁人类健康。脑血管内支架植入术改善了缺血性卒中患者的预后,但术后再狭窄是困扰其远期疗效的重大难题。气虚血瘀为缺血性脑血管病及脑血管支架植入前后的主要病理状态,补阳还五汤作为益气活血化瘀的代表方,可以通过抑制炎症反应、改善缺血再灌注的细胞供氧、改善血管内皮细胞功能、抑制血管平滑肌细胞增殖、抑制增生内膜中细胞外基质的合成并促进其清除和降解等多个环节,防治支架植入术后再狭窄。
Ischemic cerebrovascular disease poses a serious threat to human health.Cerebrovascular stent implantation improves the prognosis of ischemic stroke patients,but postoperative restenosis remains a major challenge that hinders its long-term efficacy.Qi deficiency and blood stasis are the primary pathological states of ischemic cerebrovascular disease,both before and after cerebral vascular stent implantation,Buyang Huanwu Decoction,as a representative formula for tonifying qi,promoting blood circulation,and resolving blood stasis,has demonstrated significant clinical efficacy in preventing and treating restenosis after stent implantation.This article will review the mechanisms of restenosis following cerebrovascular stent implantation and the clinical applications and mechanisms of Buyang Huanwu Decoction in preventing and treating post-stent restenosis.
作者
高乐女
陈大为
王勇
GAO Lenyu;CHEN Dawei;WANG Yong(Department of Traditional Chinese Medicine and Rheumatology,First Affiliated Hospital of Army Medical University,Chongqing 400038,China;Department of Rehabilitation Medicine,Key Laboratory of Physical Medicine and Precision Rehabilitation of Chongqing Municipal Health Commission,First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)
出处
《世界科学技术-中医药现代化》
北大核心
2025年第3期770-775,共6页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
重庆市技术创新与应用发展项目(重庆市科技发展基金会)(CSTB2024TIAD-KJFZMSX0015):益气活血方通过调节内皮细胞促进血管新生改善缺血性脑卒中预后的疗效及机制研究(958代管),负责人:高乐女。
关键词
缺血性脑血管病
支架植入术后再狭窄
益气活血化瘀
补阳还五汤
Ischemic cerebrovascular disease
Restenosis after stent implantation
Tonifying qi promoting blood circulation and resolving blood stasis
Buyang Huanwu Decoction
