摘要
为控制甲磺酸仑伐替尼原料药的质量以及推动其质量标准的建立,定向合成了甲磺酸仑伐替尼3种杂质6-氨基甲酰基-4-(3-氯-4-(3-环丙基脲基)苯氧基)-7-甲氧基喹啉-1-氮氧化物(有关物质A)、4-(3-氯-4-脲基苯氧基)-7-甲氧基喹啉-6-甲酰胺(有关物质B)和4-(4-氨基-3-(4-氨基-3-氯苯氧基)苯氧基)-7-甲氧基喹啉-6-甲酰胺(有关物质C)。3种杂质结构均经MS、^(1)H-NMR、^(13)C-NMR确证,可用于甲磺酸仑伐替尼原料药的质量研究。
In order to control the quality of the raw material of lenvatinib mesylate and promote the establishment of its quality standards,three impurities of lenvatinib mesylate were synthesized,includings 6-aminoformyl-4-(3-chloro-4-(3-cyclopropyluryl)phenoxyl)-7-methoxyquinoline-1-nitrogen oxide(related substance A),4-(3-chloro-4-urylphenoxyl)-7-methoxyquinolin-6-formamide(related substance B)and 4-(4-amino-3-(4-amino-3-chlorophenoxyl)phenoxyl)-7-methoxylquinolin-6-formamide(related substance C).The three impurity structures were confirmed by MS,^(1)H-NMR and^(13)C-NMR,which can be used for the quality study of the raw material of lenvatinib mesylate.
作者
马雪龙
唐猛
MA Xue-long;TANG Meng(Nanjing Chia-Tai Tianqing Pharmaceutical Co.,Ltd.,Nanjing 210046,China)
出处
《精细与专用化学品》
2025年第6期34-37,共4页
Fine and Specialty Chemicals
关键词
甲磺酸仑伐替尼
有关物质
合成
结构确证
lenvatinib mesilate
related substances
synthesis
structural identification
