摘要
目的对于骨科急性和慢性疼痛患者给予曲安奈德、利多卡因和甲钴胺联合封闭治疗的临床效果分析。方法方便选取2020年1月—2022年1月海阳市中医医院收治的80例骨科急性和慢性疼痛患者为研究对象,按治疗方法分为两组,每组40例。对照组行曲安奈德与利多卡因封闭治疗,观察组在对照组基础上加用甲钴胺治疗。比较两组临床疗效、疼痛因子水平、疼痛评分、生活质量评分及不良反应。结果两组治疗总有效率比较,差异有统计学意义(P<0.05)。经治疗后,两组血清神经肽Y(neuropeptide Y,NPY)、5-羟色胺(5-hydroxytryptamine,5-HT)、P物质(substance P,SP)、前列腺素E2(prostglandin E2,PGE2)水平低于治疗前,且观察组NPY(121.12±10.44)pg/mL、5-HT(0.64±0.15)μmol/L、SP(258.88±24.43)μg/mL、PGE2(59.43±7.27)ng/mL水平低于对照组的(143.56±10.29)pg/mL、(0.81±0.24)μmol/L、(276.69±25.87)μg/mL、(64.46±9.95)ng/mL,差异均有统计学意义(t=9.681,3.798,3.165,2.581;P均<0.05)。且观察组疼痛评分低于对照组,生活质量评分高于对照组,差异均有统计学意义(P均<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论治疗骨科急性和慢性疼痛患者时,在曲安奈德、利多卡因常规用药基础上,加用甲钴胺可减轻患者疼痛程度,有助于提高患者生活质量。
Objective To analyze the clinical effect of triamcinolone acetonide,lidocaine and methylcobalamin combined with closed treatment in patients with acute and chronic pain in orthopedics department.Methods Eighty patients with acute and chronic orthopedic pain admitted to Haiyang Traditional Chinese Medicine Hospital from January 2020 to January 2022 were conveniently selected as the research objects and divided into two groups according to the treatment methods,with forty patients in each group.The control group was treated with triamcinolone acetonide and lidocaine block therapy,and the observation group was treated with mecobalamin on the basis of the treatment in the control group.The clinical efficacy,levels of pain factors,pain scores,quality of life scores,and adverse reactions were compared between the two groups.Results There was a statistically significant difference in the total effective rate between the two groups(P<0.05).After treatment,the levels of serum neuropeptide Y(NPY),5-hydroxytryptamine(5-HT),substance P(SP)and prostaglandin E2(PGE2)in the two groups were lower than those before treatment.The levels of NPY(121.12±10.44)pg/mL,5-HT(0.64±0.15)μmol/L,SP(258.88±24.43)μg/mL,PGE2(59.43±7.27)ng/mL in the observation group were lower than(143.56±10.29)pg/mL,(0.81±0.24)μmo/L,(276.69±25.87)μg/mL,(64.46±9.95)ng/mL in the control group,the differences were statistically significant(t=9.681,3.798,3.165,2.581;all P<0.05)The pain score of the observation group was lower than that of the control group,and the quality of life score was higher than that of the control group,the differences were statistically significant(both P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion When treating patients with acute and chronic orthopedic pain,adding mecobalamin on the basis of the conventional use of triamcinolone acetonide and lidocaine can relieve the pain degree of patients and help improve the quality of life of patients.
作者
朱志强
周安宁
李江涛
ZHU Zhiqiang;ZHOU Anning;LI Jiangtao(Department of Orthopedics,Haiyang Traditional Chinese Medicine Hospital,Yantai 265100,Shandong,China)
出处
《系统医学》
2025年第10期50-53,共4页
Systems Medicine
关键词
曲安奈德
利多卡因
甲钴胺
封闭治疗
骨科急慢性疼痛
Triamcinolone acetonide
Lidocaine
Mecobalamin
Block therapy
Acute and chronic orthopedic pain
