摘要
慢性心力衰竭(CHF)是多种病理因素导致的各种心血管疾病的终末阶段,其发病机制复杂。线粒体形态改变是铁死亡发生的标志,线粒体功能障碍介导铁死亡是心力衰竭发生发展的重要病理机制。在中医学中,“脾病干心”理论是从病理角度概括了脾病对心系疾病的影响,但基于“脾病干心”理论论治CHF尚缺乏科学依据。本文从CHF已知西医机制(线粒体功能障碍-铁死亡-CHF)论述“脾病干心”理论及其中药治疗,并指出中医“脾”与线粒体功能高度相似,“脾病干心”理论类似线粒体功能障碍-铁死亡-CHF,基于“脾病干心”理论采用中药治疗CHF可发挥良好疗效。
Chronic heart failure(CHF)is the terminal stage of various cardiovascular diseases which caused by multiple pathological factors,and its pathogenesis is complex.Mitochondrial morphological changes are the hallmark of ferroptosis,and mitochondrial dysfunction mediates the occurrence of ferroptosis is an important pathological mechanism in the occurrence and development of heart failure.In the traditional Chinese medicine,the"Pi disorder affecting the heart"theory summarizes the impact of spleen diseases on heart-related diseases from pathological perspective.However,there is still a lack of scientific basis for treating CHF based on"Pi disorder affecting the heart"theory.This article discusses the"Pi disorder affecting the heart"theory and the treatment with traditional Chinese medicine based on the known western medical mechanism of CHF(mitochondrial dysfunction-ferroptosis-CHF).It also points out that the"Pi"in traditional Chinese medicine is highly similar to mitochondrial function,and the"Pi disorder affecting the heart"theory is similar to mitochondrial dysfunction-ferroptosis-CHF.Based on the"Pi disorder affecting the heart"theory,using traditional Chinese medicine for treatment can achieve good therapeutic effects.
作者
刘泳君
魏佳明
林瑞芳
朱赟
李雅
郭志华
LIU Yongjun;WEI Jiaming;LIN Ruifang;ZHU Yun;LI Ya;GUO Zhihua(College of Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410208,China;The School of Pharmacy of Hunan University of Chinese Medicine,Changsha 410208,China;Department of Cardiovascular Medicine,the First Hospital of Hunan University of Chinese Medicine,Changsha 410007,China;Key Laboratory of Chinese Medicine Intelligent Diagnosis and Treatment of Chronic Diseases in General Universities of Hunan Province,Changsha 410208,China)
出处
《实用心脑肺血管病杂志》
2025年第8期85-89,共5页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
基金
国家自然科学基金资助项目(82405372,82174343)。
关键词
心力衰竭
线粒体功能障碍
铁死亡
“脾病干心”理论
Heart failure
Mitochondrial dysfunction
Ferroptosis
"Pi disorder affecting the heart"theory
