摘要
目的分析中性粒细胞计数、神经元特异性烯醇化酶(NSE)、B细胞活化因子(BAFF)对脑梗死患者继发癫痫的预测价值。方法选取2021年1月—2024年10月南通市第三人民医院收治的脑梗死患者108例为研究对象。收集患者的临床资料、中性粒细胞计数、NSE、BAFF,根据患者是否继发癫痫将其分为癫痫组(34例)和无癫痫组(74例)。脑梗死患者继发癫痫的影响因素分析采用多因素Logistic回归分析;绘制ROC曲线以分析中性粒细胞计数、NSE、BAFF及三者联合对脑梗死患者继发癫痫的预测价值。结果癫痫组梗死部位为皮质者占比、出血转化者占比、美国国立卫生研究院卒中量表(NIHSS)评分、中性粒细胞计数、NSE、BAFF高于无癫痫组,梗死面积大于无癫痫组(P<0.05)。多因素Logistic回归分析结果显示,梗死面积、NIHSS评分、中性粒细胞计数、NSE、BAFF是脑梗死患者继发癫痫的独立影响因素(P<0.05)。ROC曲线分析结果显示,中性粒细胞计数、NSE、BAFF预测脑梗死患者继发癫痫的AUC分别为0.792[95%CI(0.706~0.878)]、0.890[95%CI(0.829~0.951)]、0.893[95%CI(0.823~0.963)],三者联合预测脑梗死患者继发癫痫的AUC为0.944[95%CI(0.884~1.000)]。结论中性粒细胞计数、NSE、BAFF均对脑梗死患者继发癫痫有一定预测价值,且三者联合的预测价值更高。
Objective To explore the predictive value of neutrophil count,neuron-specific enolase(NSE)and B-cell activating factor(BAFF)for secondary epilepsy in patients with cerebral infarction.Methods A total of 108 patients with cerebral infarction admitted to Nantong Third People's Hospital from January 2021 to October 2024 were selected as the research subjects.The clinical data,neutrophil count,NSE and BAFF of the patients were collected.The patients were divided into the epilepsy group(34 cases)and the non-epilepsy group(74 cases)according to whether they had secondary epilepsy.Multivariate Logistic regression analysis was used to explore the influencing factors of secondary epilepsy in patients with cerebral infarction.ROC curve was drawn to analyze the predictive value of neutrophil count,NSE,BAFF and their combination for secondary epilepsy in patients with cerebral infarction.Results The proportion of patients with cortical infarction,the proportion of patients with hemorrhagic transformation,the National Institutes of Health Stroke Scale(NIHSS)score,neutrophil count,NSE and BAFF in the epilepsy group were higher than those in the non-epilepsy group,and the infarction area was larger than that in the nonepilepsy group(P<0.05).The results of multivariate Logistic regression analysis showed that infarction area,NIHSS score,neutrophil count,NSE,and BAFF were independent influencing factors for secondary epilepsy in patients with cerebral infarction(P<0.05).The results of ROC curve analysis showed that the AUC of neutrophil count,NSE and BAFF in predicting secondary epilepsy in patients with cerebral infarction was 0.792[95%CI(0.706-0.878)],0.890[95%CI(0.829-0.951)]and 0.893[95%CI(0.823-0.963)],respectively.The AUC of their combination in predicting secondary epilepsy in patients with cerebral infarction was 0.944[95%CI(0.884-1.000)].Conclusion Neutrophil count,NSE and BAFF all have certain predictive value for secondary epilepsy in patients with cerebral infarction,and the predictive value of their combination is higher.
作者
杨颖
戴轶伟
成云芳
YANG Ying;DAI Yiwei;CHENG Yunfang(Department of Neurology,Nantong Third People's Hospital,Nantong 226000,China)
出处
《实用心脑肺血管病杂志》
2025年第8期64-68,共5页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
基金
江苏省科技计划项目(BK20232014)。
