摘要
目的:分析溴己新联合头孢呋辛钠治疗小儿肺炎的临床效果。方法:选取2021年1月—2023年12月常熟市支塘人民医院收治的96例肺炎患儿进行研究,采用随机数字表法分为两组,每组48例。对照组应用头孢呋辛钠治疗,观察组应用溴己新联合头孢呋辛钠治疗。对比两组临床疗效、临床症状改善时间、肺功能指标以及炎性因子水平。结果:观察组治疗总有效率高于对照组(P<0.05)。观察组肺部啰音、发热、咳嗽改善时间早于对照组(P<0.001)。治疗前,两组用力肺活量占预计值的百分比(FVC%pred)、第1秒用力呼气容积占预计值的百分比(FEV_(1)%pred)、FEV_(1)/FVC对比,差异无统计学意义(P>0.05);治疗后,两组FVC%pred、FEV_(1)%pred、FEV_(1)/FVC提高,且观察组高于对照组(P<0.05)。治疗前,两组降钙素原(PCT)、白细胞介素-10(IL-10)及白细胞介素-6(IL-6)水平对比,差异无统计学意义(P>0.05);治疗后,两组PCT、IL-6水平下降,且观察组低于对照组;两组IL-10水平提高,且观察组高于对照组(P<0.001)。结论:溴己新联合头孢呋辛钠治疗小儿肺炎的临床效果显著,能够改善患儿肺功能,降低炎性因子水平,促进症状缓解。
Objective:To analyze the clinical effect of bromhexine combined with cefuroxime sodium in the treatment of pediatric pneumonia.Methods:Ninety-six pediatric pneumonia patients admitted to Zhitang People's Hospital in Changshu City from January 2021 to December 2023 were selected for the study and divided into two groups using a random number table method,with 48 cases in each group.The control group was treated with cefuroxime sodium,while the observation group was treated with bromhexine plus cefuroxime sodium.The clinical efficacy,improvement time of clinical symptoms,pulmonary function indicators,and inflammatory factor levels were compared between the two groups.Results:The overall response rate in the observation group was higher than that in the control group(P<0.05).The improvement time of pulmonary rales,fever,and cough in the observation group was earlier than that in the control group(P<0.001).Before treatment,there were no statistically significant differences in the percentage of forced vital capacity to predicted value(FVC%pred),percentage of forced expiratory volume in 1 second to predicted value(FEV_(1)%pred),and FEV_(1)/FVC ratio between the two groups(P>0.05).After treatment,the FVC%pred,FEV_(1)%pred,and FEV_(1)/FVC increased in both groups,and these parameters in the observation group were higher than those in the control group(P<0.05).Before treatment,there were no statistically significant differences in the levels of procalcitonin(PCT),interleukin-10(IL-10),and interleukin-6(IL-6)between the two groups(P>0.05).After treatment,the PCT and IL-6 levels decreased in both groups,and the levels in the observation group were lower than those in the control group;while the IL-10 levels increased in both groups,and the levels in the observation group were higher than those in the control group(P<0.001).Conclusion:The clinical effect of bromhexine combined with cefuroxime sodium in treating pediatric pneumonia is significant,which can improve pulmonary function of children,reduces inflammatory factor levels,and promotes symptom relief.
作者
顾晓红
Gu Xiaohong(Department of Pediatrics,Zhitang People's Hospital in Changshu City,Changshu 215531,Jiangsu Province,China)
出处
《中国社区医师》
2025年第15期28-30,共3页
Chinese Community Doctors
关键词
儿童
肺炎
溴己新
头孢呋辛钠
肺功能
炎性因子
Children
Pneumonia
Bromhexine
Cefuroxime sodium
Pulmonary function
Inflammatory factor
