摘要
2023年2月,北京大学人民医院呼吸与危重症医学科收治1例48岁中年男性患者,主因咳嗽、咳痰就诊,CT提示纵隔气管隆突下可见一团块软组织密度灶,纵隔脓肿穿刺液的宏基因组学二代测序提示惠普尔养障体感染,过碘酸-希夫染色阳性,既往无腹泻、体质量减轻、关节疼痛史,诊断为惠普尔病,予头孢曲松序贯复方磺胺甲噁唑治疗。患者出院后接受抗感染治疗1年,临床症状明显改善,一般情况良好,继续随访中。
In February 2023,a 48-year-old male with cough and expectoration was admitted to the Department of Pulmonary and Critical Care Medicine of Peking University People’s Hospital.CT indicated mediastinal soft-tissue mass under the tracheal carina.Meta-genomics next generation sequencing of mediastinal abscess suggested infection with Tropheryma whipplei,which was positive for periodic acid-Schiff staining.The patient had no history of diarrhea,weight loss,or joint pain.The patient was diagnosed with Whipple’s disease and treated with ceftriaxone followed by trimethoprim-sulfamethoxazole therapy.After 1-year post-discharge therapy,the patieny’s symptoms and general condition improved significantly,and remained to follow.
作者
黄正义
毕陶然
卢冰冰
高占成
HUANG Zhengyi;BI Taoran;LU Bingbing;GAO Zhancheng(Department of Geriatrics,Peking University People’s Hospital,Beijing 100044,China;Department of Pulmonary and Critical Care Medicine,Peking University People’s Hospital,Beijing 100044,China)
出处
《中国临床医学》
2025年第3期519-523,共5页
Chinese Journal of Clinical Medicine
基金
北京市自然科学基金(7242152)。
关键词
惠普尔病
惠普尔养障体
宏基因组学二代测序
纵隔脓肿
Whipple’s disease
Tropheryma whipplei
meta-genomics next generation sequencing
mediastinal abscess
