摘要
Central nervous system(CNS) axons fail to regenerate following brain or spinal cord injury(SCI),which typically leads to permanent neurological deficits.Peripheral nervous system axons,howeve r,can regenerate following injury.Understanding the mechanisms that underlie this difference is key to developing treatments for CNS neurological diseases and injuries characterized by axonal damage.To initiate repair after peripheral nerve injury,dorsal root ganglion(DRG) neurons mobilize a pro-regenerative gene expression program,which facilitates axon outgrowth.
基金
supported by the Canada Foundation for Innovation (Project#44220)
the Natural Sciences and Engineering Research Council of Canada (RGPIN-2024-03986)
the Michael Smith Foundation for Health Research BC
the financial support of Health Canada,through the Canada Brain Research Fund,an innovative partnership between the Government of Canada (through Health Canada),Brain Canada Foundation
the Azrieli Foundation
supported by a Canadian Institutes of Health Research (CIHR) Canada Graduate Scholarship–Master’s Award。
