摘要
Human respiratory syncytial virus(RSV)is a major cause of lower respiratory tract infections in infants and young children,as well as an important cause of respiratory tract infections in immunocompromised patients and the elderly,which poses a significant economic and social burden worldwide.In recent years,substantial progress has been made in understanding the structure and function of RSV proteins and the interactions between RSV with host factors which is helpful to the discovery of new therapeutic targets and the development of novel interventions.Although two vaccines and two monoclonal antibodies for RSV prevention have been approved,the antiviral treatment remains an unmet clinical need.In this review,we summarize the structure,protein functional properties,and pathological mechanisms of RSV and the current status of RSV drug development.In addition,remaining challenges and innovative ideas for RSV prevention and treatment have also been highlighted.
基金
supported by foundation CAMS Innovation Fund for Medical Sciences(2021-I2M-1-030 and 2021-I2M-1-048,China)
National Natural Science Foundation of China(82394465,82394464,82394460,and 82204263)
National Science and Technology Major Projects for“Major New Drugs Innovation and Development”(2018ZX09711003,China).
