摘要
Viruses constitute a significant group of pathogens that have caused numerous fatalities and substantial economic losses in recent years,particularly with the emergence of coronaviruses.While the impact of SARS-CoV-2 appears to be diminishing in daily life,only a limited number of drugs have received approval or emergency use authorization for its treatment.Given the high mutation rate of viral genomes,host-directed agents(HDAs)have emerged as a preferred choice due to their broad applicability and lasting effectiveness.In contrast to direct-acting antivirals(DAAs),HDAs offer several advantages,including broad-spectrum antiviral activities,potential efficacy against future emerging viruses,and a lower likelihood of inducing drug resistance.In our review article,we have synthesized known host-directed antiviral targets that span diverse cellular pathways and mechanisms,shedding light on the intricate interplay between host cells and viruses.Additionally,we have provided a brief overview of the development of HDAs based on these targets.We aim for this comprehensive analysis to offer valuable perspectives and insights that can guide future antiviral research and drug development efforts.
基金
supported by the National Program for Support of Top-notch Young Professionals(Grant No.0106514050 to Yonghui Zhang,China)
the National Natural Science Foundation of China(Grant Nos.82273811 and U22A20380 to Yonghui Zhang)
the National Key Research and Development Program of China(Grant No.2021YFA0910500 to Yonghui Zhang)
TongjiRongcheng Center for Biomedicine,Huazhong University of Science and Technology。
