摘要
目的:探讨妊娠期糖尿病(GDM)孕妇血糖化血红蛋白(HbA1c)水平与组织多普勒成像与时间-空间相关成像(TDI-STIC)技术胎儿心功能参数关系。方法:回顾性选取2021年1月-2023年8月本院收治的GDM孕妇97例为观察组,产前检查健康孕妇90例纳入对照组。比较两组孕妇血HbA1c水平及其TDI-STIC胎儿心功能参数。结果:观察组二尖瓣环舒张早期峰值速度(Ea)/舒张晚期峰值速度(Aa)的比值(Ea/Aa)低于对照组,左右心室Tei指数、左/右心室壁舒张末期厚度(LVWD/RVWD)、左/右心室壁收缩末期厚度(LVWS/RVWS)、室间隔舒张末期厚度(IVSD)、室间隔收缩末期厚度(IVSS)高于对照组,血HbA1c水平高于对照组(均P<0.05)。Pearson相关分析显示,GDM孕妇外周血HbA1c水平与LVWD、RVWD、LVWS、RVWS、IVSD、左右心室Tei指数呈正相关,与二尖瓣环Ea/Aa呈负相关(均P<0.05)。结论:GDM孕妇外周血HbA1c水平及TDI-STIC技术胎儿心功能参数出现异常,提示应对GDM孕妇加以关注,以指导临床干预。
Objective:To explore the correlation between the glycated hemoglobin(HbAlc)level of pregnant women with gestational diabetes mellitus(GDM)and their values of the fetal heart function parameters evaluated by tissue Doppler imaging and time'space correlation imaging(TDI-STIC)technology.Methods:A total of 97 pregnant women with GDM admitted to the hospital from January 2021 to August 2023 were selected in observation group retrospectively,and 90 healthy pregnant women during the same period were selected in control group.The maternal peripheral HbAlc level and the fetal cardiac function parameters evaluated by TDI-STIC were compared between the two groups.Results:The ratio of the mitral annulus early diastolic peak velocity(Ea)/late diastolic peak velocity(Aa)(Ea/Aa)of the fetuses in the observation group was significantly lower than that of the fetuses in the control group.The left and right ventricular Tei index,the ratio of left/right ventricular wall end-diastolic thickness(LVWD/RVWD),the ratio of left/right ventricular wall end-systolic thickness(LVWS/RVWS),the interventricular septal end-diastolic thickness(IVSD)and the interventricular septal end-systolic thickness(IVSS)of the fetuses in the observation group were significantly higher than those of the fetuses in the control group.The peripheral HbAlc level of the women in the observation group was significantly higher than that of the women in the control group(all P<0.005).Pearson correlation analysis showed that the peripheral HbAlc level of the pregnant women with GDM was positively correlated with their values of LVWD,RVWD,LVWS,RVWS,IVSD,left and right ventricular Tei index,and was negatively correlated with their mitral annulus Ea/Aa ratio(all P<0.05).Conclusion:The peripheral blood HbAlc level and the fetal cardiac function parameters evaluated by TDI-STIC technology of the pregnant women with GDM are abnormal,and which suggests that the changes of the above indicators of the pregnant women with GDM should be paid to in clinic to guide their clinical intervention.
作者
周海霞
马湛
赵丽娟
王璐
张鹏杰
岳红利
ZHOU Haixia;MA Zhan;ZHAO Lijuan;WANG Lu;ZHANG Pengjie;YUE Hongli(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan Province,450000)
出处
《中国计划生育学杂志》
2025年第6期1386-1390,共5页
Chinese Journal of Family Planning
关键词
妊娠期糖尿病
胎儿心功能
组织多普勒成像
时间-空间相关成像
糖化血红蛋白
相关性
Gestational diabetes mellitus
Fetal heart function
Tissue Doppler imaging
Time-space correlation imaging
Glycosylated hemoglobin
Correlation
