摘要
细胞外基质(Extracellular Matrix,ECM)是由各种蛋白质、多糖等组成的细胞周围网状结构,对于维持正常组织器官的功能至关重要。ECM的异常沉积和修饰可能会导致病理状况的发生,例如纤维化和肿瘤的发生和发展。细胞外体积分数(Extracellular Volume Fraction,ECV)作为一个新的无创性量化ECM的参数,可以反映肿瘤的微环境状态并评估组织纤维化程度,在腹部脏器纤维化程度评估和腹部肿瘤组织分化程度预测、肿瘤类型鉴别诊断、治疗疗效评价等方面对临床医生具有很大的价值。本文围绕CT-ECV的测量方法及其在腹部疾病的应用展开综述,以期为腹部疾病的诊疗提供新技术和新思路,从而提高腹部疾病诊疗水平。
The extracellular matrix(ECM),a pericellular network composed of various proteins,polysaccharides,and other components,is essential for maintaining the function of normal tissues and organs.Abnormal deposition and modification of ECM may lead to pathological conditions,such as the occurrence and progression of fibrosis and tumors.As a novel non-invasive parameter for quantifying ECM,the extracellular volume fraction(ECV)can reflect the microenvironment of tumors and evaluate the degree of tissue fibrosis.It holds significant clinical value for clinicians in assessing the severity of abdominal organ fibrosis,predicting the differentiation of abdominal tumor tissues,differentiating tumor types,and evaluating treatment efficacy.This article reviewed the measurement of CT-ECV and its applications in abdominal diseases,aiming to provide new technologies and perspectives for the diagnosis and treatment of abdominal diseases and improve the level of clinical management.
作者
苗瑜瑜
武志峰
MIAO Yuyu;WU Zhifeng(School of Medical Imaging,Shanxi Medical University,Taiyuan Shanxi 030001,China;Department of Radiology,Shanxi Bethune Hospital/Shanxi Academy of Medical Sciences,Taiyuan Shanxi 030032,China)
出处
《中国医疗设备》
2025年第6期164-169,共6页
China Medical Devices
