摘要
肾移植手术不可避免地要经历肾脏缺血和血液再灌注的过程,造成移植肾缺血再灌注损伤(IRI),其与术后早期移植物功能恢复和长期存活密切相关,且目前临床上仍缺乏明确有效的防治手段。深入研究移植肾IRI的发生机制能够为研发新型保护策略提供理论基础和科学依据,本文就肾移植IRI机制及其对移植肾的影响进行综述。
The process of kidney transplantation surgery inevitably involves a phase of kidney ischemia and reperfusion,resulting in damage to the kidney's ischemia-reperfusion injury(IRI),which is intimately linked to the initial functional recuperation and prolonged survival of the transplanted organ.Presently,definitive and efficacious methods for clinical prevention and treatment remain elusive.A thorough examination of how IRI functions in transplanted kidneys offers both theoretical and scientific foundations for creating novel protective approaches.This review discusses the mechanisms of IRI and its impact on renal allograft.
作者
李一萱
李美和
郑瑾
Li Yixuan;Li Meihe;Zheng Jin(Department of Kidney Transplantation,Organ Transplant Institute,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China)
出处
《中华移植杂志(电子版)》
2025年第1期43-49,共7页
Chinese Journal of Transplantation(Electronic Edition)
基金
国家自然科学基金项目(82170768)。
关键词
缺血再灌注损伤
肾移植
氧化应激
细胞死亡
炎症反应
Ischemia-reperfusion injury
Kidney transplantation
Oxidative stress
Cell death
Inflammation reaction
