摘要
间充质干细胞(mesenchymal stem cells,MSCs)在组织损伤修复中至关重要,其释放的细胞外囊泡(extracellular vesicle,EV)在临床生物标志物、疫苗和药物传递等领域有广泛应用前景。然而,MSCs衍生的EV(extracellular vesicles derived from mesenchymal stem cells,MSCs-EV)存在产量低、保留率低和靶向性差等问题。因此,对MSCs-EV进行工程改造以提高其性能,实现可视化研究成为热点。中药活性成分姜黄素(curcumin,CUR)具有药理作用,但生物利用度有限。利用MSCs-EV作为载体递送CUR,可解决其溶解度和生物利用度问题。该文综述了MSCs-EV的载药方式、工程化策略及其在CUR递送治疗软骨损伤疾病中的重要应用,为工程化MSCs-EV递送CUR应用于软骨修复提供依据,有望解决软骨组织修复难题。
Mesenchymal stem cells(MSCs)play a crucial role in tissue repair and regeneration,and the extracellular vesicle(EV)released by them holds great promise for applications in clinical biomarkers,vaccines,and drug delivery.However,MSCs-derived EV(MSCs-EV)face challenges such as low production yield,poor retention,and targeted delivery issues.Therefore,engineering MSCs-EV to enhance their performance and enable visual research has become a hot topic.Curcumin(CUR),an active component in traditional chinese medicine,exhibits pharmacological effects but has limited bioavailability.Using MSCs-EV as a carrier for CUR delivery can address its solubility and bioavailability challenges.This article reviews the drug loading methods,engineering strategies of MSCs-EV,and their important applications in the delivery and treatment of CUR for cartilage injury diseases.It provides a basis for the clinical application of engineered MSCs-EV in CUR delivery for cartilage repair,offering potential solutions to the challenges in cartilage tissue repair.
作者
杜晓明
马钰林
段学庆
杨照熙
张宪哲
章津铭
胡一梅
DU Xiao-ming;MA Yu-lin;DUAN Xue-qing;YANG Zhao-xi;ZHANG Xian-zhe;ZHANG Jin-ming;HU Yi-mei(Dept of Orthopedics,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;School of Clinical Medicine,Chengdu University of Traditional Chinese Medicine,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)
出处
《中国药理学通报》
北大核心
2025年第7期1222-1226,共5页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 82174262)
成都中医药大学附属医院科研能力“百人计划”(No 22-Y14)。
关键词
姜黄素
间充质干细胞
细胞外囊泡
软骨
工程化
骨关节炎
curcumin
mesenchymal stem cells
extracellular vesicles
cartilage
tissue engineering
osteoarthritis
