摘要
目的:观察火针联合盐酸多西环素片治疗中重度痤疮的临床疗效。方法:选取2023年12月—2024年9月在南昌市洪都中医院皮肤科门诊治疗的99例中重度痤疮患者为研究对象,使用随机数字表法分为观察组、对照A组和对照B组各33例。观察组给予火针联合盐酸多西环素片治疗,对照A组单纯使用火针治疗,对照B组单纯口服盐酸多西环素片治疗。3组均治疗4周。比较3组临床疗效以及治疗前后痤疮综合分级系统(GAGS)、痤疮瘢痕临床评分量表(ECCA)、痤疮引起的色素沉着(AMH)评分,观察不良反应发生情况。结果:治疗4周后,观察组总有效率93.55%(29/31),对照A组总有效率83.33%(25/30),对照B组总有效率60.71%(17/28)。观察组总有效率均高于对照A组和对照B组(P<0.017),对照A组总有效率高于对照B组(P<0.017)。3组GAGS评分均较治疗前降低(P<0.05),观察组GAGS评分均低于对照A组、对照B组(P<0.017),对照A组GAGS评分低于对照B组(P<0.017)。3组ECCA、AMH评分均较治疗前升高(P<0.05),观察组ECCA、AMH评分均低于对照A组、对照B组(P<0.017)。对照A组与对照B组ECCA、AMH评分比较,差异均无统计学意义(P>0.017)。3组治疗过程中均未见明显不良反应发生。结论:火针联合盐酸多西环素片治疗中重度痤疮,在改善痤疮炎症性皮损、抑制痤疮炎症后色素沉着及瘢痕形成方面疗效均优于单纯使用盐酸多西环素片或火针治疗,且安全性良好。
Objective:To observe the clinical efficacy of fire needling combined with Doxycycline Hyclate Tablets in treating moderate-to-severe acne.Methods:A total of 99 patients with moderate-to-severe acne treated at Nanchang Hongdu Hospital of Traditional Chinese Medicine from December 2023 to September 2024 were divided into the observation group,the control group A,and the control group B according to the random number table method,with 33 cases in each group.The observation group received fire needling combined with Doxycycline Hyclate Tablets,the control group A received fire needling alone,and the control group B received Doxycycline Hyclate Tablets alone.All groups were treated for four weeks.Clinical efficacy was compared,along with the Global Acne Grading System(GAGS)scores,Échelle d'Évaluation Clinique des Cicatrices d'Acné(ECCA)scores,and Acne-Induced Melanin Hyperpigmentation(AMH)scores before and after treatment.Adverse reactions were also observed.Results:After four weeks of treatment,the total effective rates were 93.55%(29/31)in the observation group,83.33%(25/30)in the control group A,and 60.71%(17/28)in the control group B.The observation group showed significantly higher efficacy than both control groups(P<0.017),and the control group A was more effective than the control group B(P<0.017).GAGS scores decreased in all three groups(P<0.05),with the observation group showing significantly lower scores than both control groups(P<0.017),and the control group A having lower scores than the control group B(P<0.017).ECCA and AMH scores increased in all groups(P<0.05),but were significantly lower in the observation group compared to both control groups(P<0.017).There was no statistically significant difference in ECCA and AMH scores between control group A and control group B(P>0.017).No significant adverse reactions were observed during treatment.Conclusion:Fire needling combined with Doxycycline Hyclate Tablets is more effective than either treatment alone in improving inflammatory acne lesions,inhibiting post-inflammatory hyperpigmentation,and preventing scar formation in moderate-to-severe acne,with good safety.
作者
姚冬梅
陈娟娟
YAO Dongmei;CHEN Juanjuan(Nanchang Hongdu Hospital of Traditional Chinese Medicine,Nanchang Jiangxi 330038,China)
出处
《新中医》
2025年第12期120-125,共6页
New Chinese Medicine
基金
南昌市医疗卫生引导性科技计划项目(2023YLWS030)
江西省卫生健康委科技计划项目(202410594)。
关键词
痤疮
中重度
火针
盐酸多西环素片
色素沉着
瘢痕
Acne
Moderate-to-severe
Fire needling
Doxycycline Hyclate Tablets
Hyperpigmentation
Scar
