摘要
目的探讨复方嗜酸乳杆菌片联合蒙脱石散对轮状病毒肠炎患儿腹泻症状及肠道微生态的影响。方法选取2022年1月至2024年2月界首市人民医院接收的80例轮状病毒肠炎患儿,根据随机数字表法分为两组,其中对照组40例接受蒙脱石散治疗,观察组40例接受复方嗜酸乳杆菌片联合蒙脱石散治疗。治疗后对比两组疗效、临床症状缓解时间(发热、腹泻、止吐、脱水、大便性状)、肠道微生态(双歧杆菌、乳酸杆菌、大肠杆菌)、免疫功能(CD4^(+)、CD8^(+)、CD3^(+)、CD4^(+)/CD8^(+))、炎症反应[C反应蛋白(CRP)、肿瘤坏死因子α(TNFα)、白细胞介素(IL-1β、IL-18)]。结果观察组临床总有效率95.00%高于对照组77.50%(χ^(2)=5.441,P<0.05);观察组发热、腹泻、脱水、大便性状缓解时间及止吐时间均较对照组缩短(t=3.038、3.167、4.284、2.738、3.241,P<0.05);观察组治疗3 d后乳酸杆菌、双歧杆菌数量较对照组增加,大肠杆菌数量较对照组减少(t=2.164、2.843、3.016,P<0.05);观察组治疗3 d后CD3^(+)、CD4^(+)及CD4^(+)/CD8^(+)均高于对照组,CD8^(+)低于对照组(t=3.152、4.274、3.975、4.628,P<0.05);观察组治疗3 d后血清CRP、IL-1β、TNFα、IL-18水平均低于对照组(t=5.729、5.823、10.962、5.317,P<0.05)。结论复方嗜酸乳杆菌片、蒙脱石散二者联合应用可显著改善轮状病毒肠炎的腹泻、发热等症状,恢复肠道微生态平衡。
ObjectiveTo explore the effects of compound Lactobacillus acidophilus tablets combined with montmorillonite powder on diarrhea symptoms and intestinal microbiota in children with rotavirus enteritis.MethodsA total of 80 children with rotavirus enteritis admitted to Jieshou People's Hospital from January 2022 to February 2024 were selected,and divided into two groups according to the random number table method.The control group(40 cases)received treatment with montmorillonite powder,while the observation group(40 cases)received treatment with compound Lactobacillus acidophilus tablets combined with montmorillonite powder.After treatment,the efficacy,clinical symptom relief time(fever,diarrhea,antiemesis,dehydration,stool characteristics),gut microbiota(Bifidobacterium,Lactobacillus,Escherichia coli),and immune function(CD4^(+),CD8^(+),CD3^(+),CD4^(+)/CD8^(+)),inflammatory response[C-reactive protein(CRP),tumor necrosis factor alpha(TNFα),interleukin(IL-1β,IL-18)]were compared between the two groups.ResultsThe total clinical effective rate of the observation group was 95.00%,which was higher than that of the control group 77.50%(χ^(2)=5.441,P<0.05).The observation group had shorter fever,diarrhea,dehydration,stool characteristics relief time,and antiemetic time compared to the control group(t=3.038,3.167,4.284,2.738,3.241,P<0.05).After 3 days of treatment,the number of Lactobacilli and Bifidobacteria in the observation group increased compared to the control group,while the number of Escherichia coli decreased(t=2.164,2.843,3.016,P<0.05).CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)in the observation group were all higher than those in the control group,and CD8^(+)was lower than that in the control group(t=3.152,4.274,3.975,4.628,P<0.05).After 3 days of treatment,the levels of serum CRP,IL-1β,TNFα,and IL-18 in the observation group were lower than those in the control group(t=5.729,5.823,10.962,5.317,P<0.05).ConclusionThe combination of compound Lactobacillus acidophilus tablets and montmorillonite powder significantly improves clinical symptoms such as diarrhea and fever in rotavirus enteritis,and restores the balance of intestinal microbiota.
作者
王倩
李登峰
田永春
李秀玲
王蕊
Wang Qian;Li Dengfeng;Tian Yongchun;Li Xiuling;Wang Rui(Department of Paediatrics,Jieshou People's Hospital,Jieshou 236500,China)
出处
《中华消化病与影像杂志(电子版)》
2025年第3期277-281,共5页
Chinese Journal of Digestion and Medical Imageology(Electronic Edition)
关键词
轮状病毒肠炎
复方嗜酸乳杆菌片
蒙脱石散
腹泻
肠道微生态
Rotavirus enteritis
Compound Lactobacillus acidophilus tablets
Montmorillonite scattering
Diarrhea
Intestinal microbiota
