摘要
为制备具有优异单向导湿性的可降解Janus微纳纤维膜,利用纤维素纳米晶(CNC)对聚对二氧环己酮(PPDO)进行亲水改性,经静电纺丝制备得到CNC/PPDO亲水层,再通过逐层静电纺丝的方法在亲水层表面依次纺制PPDO本征过渡层及聚乳酸(PLA)疏水层,最终制得PPDO Janus微纳纤维膜。结果表明:CNC质量分数为15%的CNC/PPDO微纳纤维膜具有最佳的力学强度(4.39 MPa),且表面水接触角达49.5°,芯吸高度达103 mm,吸水率达190.28%,展现出优异的亲水性能。此外,本征过渡层PPDO微纳纤维膜与亲水层CNC/PPDO微纳纤维膜及疏水层PLA纤维膜间界面结合稳定,保障了水在层间的稳定流动,从而实现了PPDO Janus微纳纤维膜的单向导湿特性。这种以PPDO本征材料为过渡层的Janus微纳纤维膜在新型伤口敷料等医用领域具有应用潜力。
Poly(p-dioxanone)(PPDO)is an aliphatic polyether ester recognized for its biodegradability and biocompatibility.The unique ether bonds in the molecular chain give PPDO good flexibility and broad application prospects in biomedicine.Janus micro/nanofiber membranes have the characteristics of high specific surface area,high porosity and asymmetric wettability,which can realize the special function of directional water transport,and have the application potential in tissue patches,novel wound dressings and other fields.Electrospinning is a commonly used method for preparing Janus fiber membranes,which can obtain micro/nanofiber membranes with diverse structures and functions by adjusting process parameters and coordinating multiple technologies.However,the poor interfacial bonding stability of heterogeneous materials in Janus fiber membranes limits their application.In this paper,Janus fiber membranes were constructed by layer-by-layer electrospinning with the structurally controllable PPDO micro/nanofiber membrane as the intrinsic transition layer to improve the interface bonding instability of heterogeneous material caused by excessive wetting gradient.Cllulose nanocrystals(CNC)were used for hydrophilic modification of PPDO,and the CNC/PPDO hydrophilic layer was prepared by electrospinning.Subsequently,the PPDO intrinsic transition layer and the polylactic acid(PLA)hydrophobic layer were electrospun to the surface of the hydrophilic layer by a layer-by-layer electrospinning method,which ultimately resulted in the PPDO Janus micro/nanofiber membranes.The effects of CNC contenton the performance of the hydrophilic layer,the influence of the hydrophobic layer's thickness on the unidirectional wet permeability of Janus micro/nanofiber membranes,the effect of the transition layer on the stability of interfacial bonding,and the degradability of Janus micro/nanofiber membranes were also investigated,respectively.The results showed that the fiber diameter and mechanical strength showed a first increase and then decrease pattern with the increase of the CNC content.Specifically,the CNC/PPDO fiber membrane with a CNC content of 15%has the largest fiber diameter and the best mechanical strength of 4.39 MPa.When this fiber membrane is used as the hydrophilic layer in the Janus membrane structure,it demonstrates a contact angle of 49.5°,a wicking height of 103 mm,and a water absorption rate of 190.28%.When the feed pump flow rate is 0.2 mL/h and the spinning time is in the 25-30 min range,the obtained PLA layer exhibits an appropriate thickness and stable interfacial bonding with the intrinsic transition layer of PPDO,ensuring stable-state water flow between the interface.The different diffusion performances of blue droplets in hydrophilic and hydrophobic layers indicate that water can selectively penetrate the PPDO intrinsic transition layer in the Janus structure to realize a stable unidirectional water-conducting process.The hydrophilic layer is one of the main parts that determine the degradability of Janus membrane.In vitro degradation experiments of micro/nanofiber membranes show that the addition of CNC can delay the degradation of PPDO micro/nanofiber membranes and CNC/PPDO micro/nanofiber membranes.This Janus micro/nanofiber membrane,which utilizes PPDO intrinsic material as its transition layer and is fully biodegradable,features a stable interface between hydrophilic and hydrophobic layers.It exhibits excellent unidirectional wet permeability and biodegradability,making it a promising candidate for medical applications such as novel wound dressings and tissue patches.
作者
邢瑞权
田鑫
郭俊宇
程金雪
郭敏杰
XING Ruiquan;TIAN Xin;GUO Junyu;CHENG Jinxue;GUO Minjie(College of Chemical Engineering and Materials Science,Tianjin University of Science and Technology,Tianjin 300457,China;State Key Laboratory of Biobased Fiber Manufacturing Technology,Tianjin University of Science and Technology,Tianjin 300457,China)
出处
《现代纺织技术》
北大核心
2025年第6期110-118,共9页
Advanced Textile Technology
基金
中央引导地方科技发展专项(21ZYQCSY00050)。
关键词
聚对二氧环己酮
逐层静电纺丝
Janus微纳纤维膜
纤维素纳米晶
本征过渡层
单向导湿性
poly(p-dioxanone)
layer-by-layer electrospinning
Janus micro/nanofiber membranes
cellulose nanocry-stals
intrinsic transition layer
unidirectional wet permeability
