摘要
脓毒症脑病(SAE)是严重的脓毒症神经系统并发症,其高病死率推动了对其发病分子机制的广泛研究。目前的研究已初步揭开了SAE病理生理机制的“冰山一角”,但SAE本身作用机制很复杂,导致它的发病机制不能充分阐述。高通量组学技术的出现为SAE生物标志物的鉴定及其发病机制的更深入理解奠定了基础。多组学整合技术通过整合来自基因组学、转录组学、蛋白质组学、代谢组学和微生物组学的数据,对基因、RNA、蛋白质、代谢物和微生物等因素进行综合分析,以揭示分子之间的复杂相互作用。这种多组学整合的方法为SAE的发病机制研究提供了有价值的见解,有助于确定潜在的治疗靶点和生物标志物。本综述系统总结了SAE领域中各类组学研究及其整合分析的最新进展,重点阐述了高通量组学技术在揭示SAE病理机制中的重要作用。
Sepsis-associated encephalopathy(SAE)is a severe neurological complication of sepsis,and its high mortality rate has driven extensive research into its molecular mechanisms.The current research has initially revealed the"tip of the iceberg"of the pathophysiological mechanism of SAE.However,the complex mechanism of SAE itself has not been fully elucidated.The advent of high-throughput omics technologies has laid the foundation for the identification of biomarkers for SAE and a deeper understanding of its underlying mechanisms.Multi-omics integrative approach technology integrates data from genomics,transcriptomics,proteomics,metabolomics and microbiome to comprehensively analyze factors such as genes,RNA,proteins,metabolites and microorganisms to reveal the complex interactions between molecules.This multi-omics integrative approach offers valuable insights into the pathogenesis of SAE and aids in the identification of potential therapeutic targets and biomarkers.This review systematically summarizes the latest progress in various omics studies of SAE and their integrative analysis,with a focus on the important role of high-throughput omics technologies in revealing the pathological mechanisms of SAE.
作者
陆昱汝
祝伟
LU Yv-ru;ZHU Wei(Department of Emergency Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei Wuhan 430030,China;Department of Intensive Care Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei Wuhan 430030,China)
出处
《内科急危重症杂志》
2025年第3期201-207,共7页
Journal of Critical Care In Internal Medicine
基金
湖北省重点研发计划项目(2022BCA038)。
