摘要
目的:探讨术前新辅助化疗联合腹腔镜手术治疗低位直肠癌患者的临床疗效.方法:选取2021年6月至2024年6月潢川县人民医院收治的76例低位直肠癌患者作为研究对象.采用随机数字表法,将其分为观察组(n=38,采取术前新辅助化疗联合腹腔镜手术治疗)和对照组(n=38,采取腹腔镜手术治疗).比较两组患者血清肿瘤标志物[癌胚抗原(CEA)、糖类抗原199(CA199)、糖类抗原724(CA724)、糖类抗原242(CA242)]、并发症发生率及保肛率.结果:治疗后,观察组患者血清CA199、CA724、CA242以及CEA水平低于对照组,差异均有统计学意义(P<0.05);两组患者并发症总发生率比较,差异无统计学意义(P>0.05);观察组患者保肛率(97.37%,37/38)高于对照组(78.95%,30/38),差异有统计学意义(P<0.05).结论:低位直肠癌患者使用术前新辅助化疗联合腹腔镜手术治疗可有效降低血清肿瘤标志物水平,并发症较少且保肛率较高,预后良好,具有广泛应用前景.
Objective:To explore the clinical efficacy of preoperative neoadjuvant chemotherapy combined with laparoscopic surgery in patients with low rectal cancer.Methods:A total of 76 patients with low rectal cancer treated in Huangchuan county people's hospital from June 2021 to June 2024 were selected as research subjects.They were divided into observation group(n=38,treated with preoperative neoadjuvant chemotherapy combined with laparoscopic surgery)and control group(n=38,treated with laparoscopic surgery),according to random number table method.The serum tumor markers[carcinoembryonic antigen(CEA),carbohydrate antigen(CA)199,CA724,CA242],complication rate and anal preservation rate were compared between the two groups.Results:After treatment,the serum levels of CA199,CA724,CA242 and CEA in observation group were lower than those in control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of complications between the two groups(P>0.05).The rate of anal preservation in observation group(97.37%,37/38)was higher than that in control group(78.95%,30/38),and the difference was statistically significant(P<0.05).Conclusion:Preoperative neoadjuvant chemotherapy combined with laparoscopic surgery is effective in the treatment of patients with low rectal cancer,which can effectively reduce the level of serum tumor markers,the patients have fewer complications and higher anal preservation rate,and have a good prognosis,which has a wide application prospect.
作者
夏桥波
郑巍巍
XIA Qiaobo;ZHENG Weiwei(Department of General Surgery,Huangchuan County People's Hospital,Xinyang 465150,China;Department of Gastrointestinal Surgery,Henan Provincial People's Hospital,Zhengzhou 450000,China)
出处
《四川解剖学杂志》
2025年第1期30-32,共3页
Sichuan Journal of Anatomy
关键词
低位直肠癌
腹腔镜手术
术前新辅助化疗
血清肿瘤标志物
预后效果
Low rectal cancer
Laparoscopic surgery
Preoperative neoadjuvant chemotherapy
Serum tumor markers
Prognostic effect
