摘要
Objective:To identify the efficacy of Wolbachia-based intervention by reviewing community-based trials through meta-analysis and systematic review methods.Methods:Studies about Wolbachia-infected mosquito intervention were collected through a screening process.Records underwent data extraction and quality assessment independently by the authors.The primary outcome of the study was protective efficacy.Quantitative analysis was conducted through meta-analysis and multivariate meta-regression using Rstudio Ver.2024.09.0-375.Qualitative analysis was done by summarizing records’findings.Results:10 out of the 10660 records met the criteria.The evidence was moderate in quality and highly heterogeneous.Intervention consisted of releasing Wolbachia-infected Aedes aegypti in densely populated settlements.The combined protective efficacy of Wolbachia intervention against dengue is highly heterogeneous(79%;95%CI 70-88;I^(2)=98%).wMel strain is significantly more efficacious compared to wAlbB(protective efficacy 84%;95%CI 76-93;I^(2)=95%)vs.64%(95%CI 46-82;I^(2)=85%);P<0.01)in preventing dengue cases.Wolbachia-infected mosquito populations were found to be unstable upon release cessation,which necessitated periodic release and monitoring to maintain desired concentration and protective efficacy.Conclusions:Wolbachia-based intervention is effective in suppressing the transmission of mosquito-borne diseases,especially dengue,with an excellent safety profile.However,community acceptance and policy remain as significant barriers to implementation.
