摘要
目的:探究宣白承气汤用于结直肠癌术后肺热肠燥证患者的效果。方法:收集2021年1月—2023年10月在北京中医医院手术的结直肠癌患者96例,随机分为对照组和宣白承气汤组,每组48例,对照组行术后常规治疗,宣白承气汤组在对照组基础上加用宣白承气汤治疗,比较两组患者术后1 d、术后7 d血清胃肠道激素水平,记录胃肠道功能恢复情况,测量术后1 d、术后7 d患者肺功能指标、T淋巴细胞亚群,记录患者切口感染、肺部感染等并发症。结果:术后7 d血清胃动素(MTL)及胃泌素(GAS)水平比较,宣白承气汤组显著高于对照组(P<0.01);宣白承气汤组首次排便时间、肠鸣音恢复时间、首次排气时间、首次进食时间均显著短于对照组(P<0.01);术后7 d第1秒用力呼气量(FEV 1)及用力肺活量(FVC)比较,宣白承气汤组显著高于对照组(P<0.01);术后7 d宣白承气汤组CD3^(+)、CD4^(+)水平高于对照组,CD8^(+)水平低于对照组(P<0.01);切口感染、肺部感染等并发症总发生率对比,宣白承气汤组显著低于对照组(P<0.05)。结论:结直肠癌术后肺热肠燥证患者接受宣白承气汤治疗可调节其胃肠道激素水平,促进胃肠功能恢复,并可改善患者肺功能及免疫功能,降低术后并发症发生风险。
Objective:To explore the effects of Xuanbai Chengqi Decoction on colorectal cancer patients with lung-heat and intestinal-dryness syndrome after surgery.Methods:A total of 96 colorectal cancer patients who underwent surgery at Beijing Hospital of Traditional Chinese Medicine from January 2021 to October 2023 were randomly divided into the control group and the Xuanbai Chengqi Decoction group,with 48 patients in each group.The control group received routine postoperative treatment,while the Xuanbai Chengqi Decoction group was additionally treated with Xuanbai Chengqi Decoction.Serum gastrointestinal hormone levels were measured on postoperative day 1 and day 7.Gastrointestinal function recovery was recorded,and pulmonary function indicators,T lymphocyte subgroups,as well as complications such as incision infections and pulmonary infections,were monitored.Results:On postoperative day 7,the serum motilin(MTL)and gastrin(GAS)levels in the Xuanbai Chengqi Decoction group were significantly higher than those in the control group(P<0.01).The first defecation time,recovery time of bowel sounds,first passing of gas time,and first feeding time in the Xuanbai Chengqi Decoction group were all significantly shorter than in the control group(P<0.01).On postoperative day 7,the forced expiratory volume in 1 second(FEV1)and forced vital capacity(FVC)in the Xuanbai Chengqi Decoction group were significantly higher than those in the control group(P<0.01).The levels of CD3^(+)and CD4^(+)T cells in the Xuanbai Chengqi Decoction group were higher,while the CD8^(+)T cell level was lower than those in the control group(P<0.01).The total incidence of complications,including incision infections and pulmonary infections,was significantly lower in the Xuanbai Chengqi Decoction group compared to the control group(P<0.05).Conclusion:Xuanbai Chengqi Decoction treatment in colorectal cancer patients with lung-heat and intestinal-dryness syndrome after surgery can regulate gastrointestinal hormone levels,promote gastrointestinal function recovery,improve pulmonary function and immune function,and reduce the risk of postoperative complications.
作者
于淼
陈谦
张洪海
梁燕凯
冀祯
路夷平
YU Miao;CHEN Qian;ZHANG Honghai;LIANG Yankai;JI Zhen;LU Yiping(Department of Oncology Surgery/General Surgery,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China)
出处
《中医药学报》
2025年第5期74-78,共5页
Acta Chinese Medicine and Pharmacology
基金
北京市属医院科研培育计划项目(pz2022008)。
关键词
宣白承气汤
结直肠癌
胃肠道功能恢复情况
胃肠道激素
T淋巴细胞
Xuanbai Chengqi Decoction
Colorectal cancer
Gastrointestinal function recovery
Gastrointestinal hormones
T lymphocytes
