摘要
本文报道两项发现:(1)心脏冠状动静脉血管周围间隙内组织液定向流动图像和运动学基本定律;(2)心肺间组织液定向流动图像和运动学基本定律.借助荧光示踪技术,我们发现了如下新现象:(a)心脏血管树上,组织液沿分支血管周围间隙(Perivascular Space,次流道PVS)向主血管周围间隙(Perivascular and Adventitial Clearances,主流道PAC)汇集,形成聚合流动;(b)心脏主血管周围间隙(主流道PAC)内,组织液从心尖向心底方向流动,构成心脏冠状血管周围间隙内组织液循环;(c)主流道PAC和分支流道PVS内,组织液流动满足三大基本定律,即存在律、同向律和反向律;(d)组织液由心到肺流动,构成心肺间组织液循环;(e)基于外周、心脏和心肺间组织液流动图像,完成全身性组织液流动的“拼图游戏”,建构出生命体内组织液循环图像;(f)组织液循环与血液循环偶联,建构对偶型内外双循环图像.
This paper reports two key findings:(1)the directional flow patterns and fundamental kinematics of interstitial fluid(ISF)within the perivascular spaces surrounding the coronary arteries and veins,and(2)the directional flow patterns and fundamental kinematics of ISF in the cardiopulmonary interstitial space.Using fluorescent tracer technology,we observed the following novel phenomena:(a)In the cardiac vascular tree,ISF flows from the perivascular space surrounding branching vessels(Perivascular Space,secondary conduit PVS)toward the perivascular and adventitial clearances surrounding the main blood vessels(Perivascular and Adventitial Clearances,main conduit PAC),forming the aggregated flow;(b)Within the main blood vessel perivascular and adventitial clearances(main conduit PAC),ISF flows from the apex of the heart toward the base,forming the ISF circulation within the coronary vascular clearances;(c)Within both the main conduit PAC and secondary conduit PVS,the flow of ISF follows three fundamental laws:the existence law,the co-directional law,and the counter-directional law;(d)ISF flows from the heart to the lungs,forming the cardiopulmonary interstitial fluid circulation;(e)Based on the flow patterns of ISF in the peripheral,cardiac,and cardiopulmonary interstitial spaces,we completed the"puzzle"of systemic ISF flow,constructing the image of ISF circulation within living organisms;(f)The ISF circulation is coupled with the blood circulation,forming a coupled dual circulation model of internal and external circulations.
作者
殷雅俊
孔钇雅
余晓彬
YIN Yajun;KONG Yiya;YU Xiaobin(Department of Engineering Mechanics,Tsinghua University,Beijing 100084,China;Department of Cardiology Beijing Tsinghua Changgung Hospital,School of Clinical Medicine,Tsinghua University,Beijing 102218,China)
出处
《力学季刊》
北大核心
2025年第2期303-312,共10页
Chinese Quarterly of Mechanics
基金
国家自然科学基金原创探索计划(12050001)。
关键词
心脏
肺
血管周围间隙
组织液循环
对偶型内外双循环
heart
lung
perivascular and adventitial clearances
interstitial fluid circulation
coupled dual internal and external circulations
