摘要
目的 探讨苯磺酸瑞马唑仑联合低剂量丙泊酚全麻在腹腔镜胆囊切除术(laparoscopic cholecystectomy,LC)中的应用效果,并评估其对患者恢复的影响。方法 随机选取2022年1月—2023年6月在咸宁市第一人民医院进行LC治疗的80例患者为研究对象。根据麻醉方式不同分为两组(传统组和探究组),每组40例。传统组应用常规剂量丙泊酚维持麻醉,探究组应用苯磺酸瑞马唑仑联合低剂量丙泊酚进行麻醉维持,比较两组血流动力学指标变化、术后苏醒恢复情况及不良反应发生情况。结果 在手术过程中的T_(1)、T_(2)、T_(3)时刻,探究组在心率、收缩压及舒张压方面相较于传统组表现出更为平稳的趋势,差异均有统计学意义(P均<0.05)。术后5、10、30 min,探究组的苏醒恢复情况优于传统组,差异均有统计学意义(P均<0.05)。探究组不良反应发生率为7.50%(3/40)低于传统组的27.50%(11/40),差异有统计学意义(χ^(2)=5.541,P<0.05)。结论 苯磺酸瑞马唑仑联合低剂量丙泊酚全麻在LC中的应用效果优于单独使用低剂量丙泊酚,该联合麻醉方案能够更平稳地维持患者的生命体征,促进术后苏醒恢复,降低不良反应发生率。
Objective To investigate the application effect of remazolam benzenesulfonate combined with low-dose propofol general anesthesia in laparoscopic cholecystectomy(LC),and to evaluate its effect on the recovery of patients.Methods A total of eighty patients who underwent LC in The First People's Hospital of Xianning City from January 2022 to June 2023 were randomly selected as the study subjects.According to the different anesthesia methods,they were divided into two groups(traditional group and inquiry group),forty cases in each group.The traditional group was treated with routine dose of propofol to maintain anesthesia,and the inquiry group was treated with remazolam benzenesulfonate combined with low dose of propofol to maintain anesthesia.The changes of hemodynamic indexes,postoperative recovery and incidence condition of adverse reactions were compared between the two groups.Results At T_(1),T_(2) and T_(3) during the operation,the heart rate,systolic blood pressure and diastolic blood pressure in the inquiry group showed a more stable trend than those in the traditional group,and the differences were statistically significant(all P<0.05).At 5,10 and 30 min after operation,the recovery of the inquiry group was better than that of the traditional group,and the differences were statistically significant(all P<0.05).The incidence of adverse reactions in the inquiry group was 7.50%(3/40),which was lower than 27.50%(11/40)in the traditional group,and the difference was statistically significant(χ^(2)=5.541,P<0.05).Conclusion The application effect of remazolam benzenesulfonate combined with low-dose propofol general anesthesia in LC is better than that of low-dose propofol alone.The combined anesthesia scheme can more smoothly maintain the vital signs of patients,promote postoperative recovery and reduce the incidence of adverse reactions.
作者
王莹莹
李学斌
何智敏
WANG Yingying;LI Xuebin;HE Zhimin(The First People's Hospital of Xianning City,Xianning 437000,Hubei,China)
出处
《系统医学》
2025年第9期77-80,共4页
Systems Medicine
关键词
苯磺酸瑞马唑仑
丙泊酚
全麻
腹腔镜胆囊切除术
血流动力学
苏醒恢复
不良反应
Remazolam benzenesulfonate
Propofol
General anesthesia
Laparoscopic cholecystectomy
Hemodynamics
Resuscitation
Adverse reactions
