摘要
目的 分析利培酮联合氯氮平对精神分裂症患者症状及认知功能的改善作用。方法 便利选取2023年5月—2024年5月贵阳市精神病院收治的60例精神分裂症患者为研究对象,根据治疗方法不同将患者分为两组:对照组(n=30)接受单一利培酮治疗,观察组(n=30)采用利培酮联合氯氮平治疗方案。对比两组的精神症状、认知功能、社会功能、日常生活能力以及心肌酶谱水平、不良反应发生情况。结果 观察组阳性症状量表为(13.14±2.10)分,阴性症状量表为(12.17±2.18)分,一般精神病理症状量表为(24.15±3.33)分,均低于对照组的(17.26±2.18)分、(16.47±2.29)分、(30.35±4.28)分,差异均有统计学意义(t=7.455,7.449,6.262;P均<0.05)。观察组的认知功能、社会功能、日常生活能力评分分别为(41.15±2.16)分、(74.45±2.28)分、(73.45±2.27)分,高于对照组的(37.15±2.28)分、(69.35±3.37)分、(68.75±3.39)分,差异均有统计学意义(t=6.976,6.865,6.310;P均<0.05)。两组的肌酸激酶同工酶、肌酸激酶、乳酸脱氢酶水平都高于治疗前,差异均有统计学意义(P均<0.05),但组间对比,差异均无统计学意义(P均>0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 在精神分裂症临床治疗中联合应用利培酮和氯氮平,可以改善患者认知功能和社会功能,更好地缓解精神症状,提高日常生活能力,且不良反应在可控范围内。
Objective To analyze the improvement effect of risperidone combined with clozapine on symptoms and cognitive function in patients with schizophrenia.Methods A total of sixty patients with schizophrenia admitted to Guiyang Psychiatric Hospital from May 2023 to May 2024 were conveniently selected as the research objects.According to different treatment methods,the patients were divided into two groups:the control group(n=30)received single risperidone treatment,and the observation group(n=30)received risperidone combined with clozapine treatment.The psychiatric symptoms,cognitive function,social function,daily living ability,myocardial enzyme level and adverse reactions were compared between the two groups.Results The positive symptom scale of the observation group was 13.14±2.10,the negative symptom scale was 12.17±2.18,and the general psychopathological symptom scale was 24.15±3.33,which were lower than 17.26±2.18,16.47±2.29 and 30.35±4.28 of the control group,and the differences were statistically significant(t=7.455,7.449,6.262;all P<0.05).The scores of cognitive function,social function and daily living ability in the observation group were 41.15±2.16,74.45±2.28 and 73.45±2.27,respectively,which were higher than those in the control group 37.15±2.28,69.35±3.37,68.75±3.39,and the differences were statistically significant(t=6.976,6.865,6.310;all P<0.05).The levels of creatine kinase isoenzyme,creatine kinase and lactate dehydrogenase in the two groups were higher than those before treatment,and the differences were statistically significant(all P<0.05).However,there were no significant differences between the two groups(all P>0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of risperidone and clozapine in the clinical treatment of schizophrenia can improve the cognitive and social functions of patients,better relieve mental symptoms,improve the ability of daily living,and the adverse reactions are under control.
作者
冉慧
吴丽
闫辰
RAN Hui;WU Li;YAN Chen(Department of Psychiatry,Guiyang Psychiatric Hospital,Guiyang 550004,Guizhou,China)
出处
《系统医学》
2025年第9期61-64,共4页
Systems Medicine
关键词
精神分裂症
利培酮
氯氮平
认知功能
Schizophrenia
Risperidone
Clozapine
Cognitive function
