摘要
目的:探讨丹参注射液联合血必净注射液治疗急性胰腺炎(AP)的疗效,并分析其对临床症状改善时间、炎症介质水平的影响。方法:将开封市第三人民医院2022年8月至2023年8月收治的86例AP患者依据治疗方案分为对照组(血必净注射液治疗,n=43)、研究组(丹参注射液联合血必净注射液治疗,n=43)。统计对比两组临床疗效、不良反应、临床症状改善时间及治疗前后肠道黏膜屏障[D-乳酸(D-LAC)、二胺氧化酶(DAO)、内毒素(LPS)]、炎症介质[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)]、血管内皮功能-血小板活化[内皮素-1(ET-1)、一氧化氮(NO)、血管内皮生长因子(VEGF)、血小板α颗粒膜蛋白(GMP-140)、血栓烷B2(TXB2)]水平。结果:研究组总有效率高于对照组(P<0.05);研究组腹痛改善时间、肠鸣音改善时间、血淀粉酶恢复时间、首次排气时间均短于对照组(P<0.05);与对照组相比,研究组治疗后血清D-LAC、DAO、LPS水平降低(P<0.05);与对照组相比,研究组治疗后血清IL-6、TNF-α、IL-8水平降低(P<0.05);与对照组相比,研究组治疗后血清ET-1、VEGF、GMP-140、TXB2水平降低,NO水平升高(P<0.05);两组不良反应比较无明显差异(P>0.05)。结论:丹参注射液联合血必净注射液治疗AP的疗效确切,可缩短临床症状改善时间,改善肠道黏膜屏障功能、血管内皮功能,缓解炎症反应,抑制血小板过度活化,且具有一定安全性。
Objective:To investigate the efficacy of Salvia Miltiorrhiza injection combined with Xuebijing injection in the treatment of acute pancreatitis(AP),and to analyze its influence on the improvement time of clinical symptoms and the level of inflammatory mediators.Methods:Based on the treatment protocol,86 patients with AP admitted to the Third People's Hospital of Kaifeng from August 2022 to August 2023 were divided into a control group(treated with Xuebijing Injection,n=43)and a study group(treated with Salvia Miltiorrhiza Injection combined with Xuebijing Injection,n=43).Clinical efficacy,adverse reactions,time to clinical symptom improvement,and pre/post-treatment levels of intestinal mucosal barrier markers[D-lactate(D-LAC),diamine oxidase(DAO),lipopolysaccharide(LPS)],inflammatory mediators[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),interleukin-8(IL-8)]and vascular endothelial function-platelet activation markers[endothelin-1(ET-1),nitric oxide(NO),vascular endothelial growth factor(VEGF),plateletα-granule membrane protein(GMP-140),thromboxane B2(TXB2)]were compared between the two groups.Results:The total effective rate of the study group was higher than that of the control group(P<0.05).The improvement time of abdominal pain,bowel sound,amylase recovery time and first exhaust time in the study group were shorter than those in the control group(P<0.05).Compared with the control group,the serum D-LAC,DAO and LPS levels of the study group were decreased after treatment(P<0.05).Compared with the control group,the serum levels of IL-6,TNF-αand IL-8 in the study group were decreased after treatment(P<0.05).Compared with the control group,the serum levels of ET-1,VEGF,GMP-140 and TXB2 in the study group were decreased after treatment,while the level of NO was increased(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion:The combined use of Danshen injection and Xuebijing Injection in treating AP is effective,shortening the time for clinical symptoms to improve,enhancing intestinal mucosal barrier function and vascular endothelial function,alleviating inflammatory response,inhibiting excessive platelet activation,and demonstrating a certain level of safety.
作者
邵志彦
张高才
周小然
SHAO Zhiyan;ZHANG Gaocai;ZHOU Xiaoran(Department of Emergency,The Third People's Hospital of Kaifeng,Kaifeng 475100,China;Department of Neurology,Kaifeng Central Hospital,Kaifeng 475100,China)
出处
《黑龙江医药科学》
2025年第6期23-27,共5页
Heilongjiang Medicine and Pharmacy
基金
河南省医学科技攻关联合共建项目,编号:LHGJ20201028。
关键词
急性胰腺炎
丹参注射液
血必净注射液
疗效
炎症介质
血管内皮功能
acute pancreatitis
Danshen injection
Xuebijing injection
efficacy
inflammatory mediators
vascular endothelial function
